Figure 1

Western blots of α-Syn levels in brain stem, hippocampus, frontal cortex, and cerebellum of PDGF-α-Syn overexpressing transgenic mice. Brain stem [BS], hippocampus HP], frontal cortex [FC] and cerebellum [CVB] from PDGF-α-Syn transgenic mice and litter-mate non-transgenic mice [WT] were solubilized in RIPA buffer and analyzed by Western blots for α-Syn levels. α-Syn was normalized to β-actin. All values are expressed as percent change relative to changes observed in WT control animals. Results are from 3-4 animals per group; [*, p < 0.05] and [**, p < 0.01] compared to corresponding brain regions in WT animals. All blots are representative of samples.