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Table 1 Contractile responses to 5-CT, Ang II, and ET-1

From: Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway

   

Sigmoidal curve

Biphasic curve

 

n

K+ (mN)

Emax (%)

pEC50

Emax(1) (%)

Emax(2) (%)

pEC50(1)

pEC50(2)

5-CT

        

   Vehicle

5

6.87 ± 1.07

39.20 ± 12.09

6.92 ± 0.40

    

   SB-386023

6

7.42 ± 1.10

25.13 ± 4.75

7.28 ± 0.31

    

   SB-590885

6

5.45 ± 1.16

11.75 ± 3.43*

6.65 ± 0.25

    

Ang II

        

   Vehicle

6

7.16 ± 0.92

46.43 ± 6.78

10.11 ± 0.25

    

   SB-386023

7

7.08 ± 0.95

26.20 ± 4.37

10.15 ± 0.23

    

   SB-590885

7

5.88 ± 1.12

11.56 ± 2.72***

9.45 ± 0.96

    

ET-1

        

   Vehicle

6

7.16 ± 0.92

  

36.71 ± 12.09

128.40 ± 6.91

11.74 ± 0.20

9.17 ± 0.18

   SB-386023

7

7.08 ± 0.95

  

25.60 ± 7.40

132.20 ± 8.46

11.73 ± 0.16

8.96 ± 0.20

   SB-590885

7

5.88 ± 1.12

  

7.44 ± 2.44*

147.4 ± 11.04

11.37 ± 0.20

9.07 ± 0.08

  1. Responses were characterized by Emax values, expressed as percent of 63.5 mM K+-induced contraction, and pEC50 values. Values are represented as mean ± s.e.m., with n representing the number of patients. Statistical analyses were performed using the non-parametric Kruskal-Wallis test and Dunn´s multiple comparison test. *P < 0.05, ***P < 0.001 compared with vehicle. 5-CT - 5-carboxamidotryptamine, Ang II - Angiotensin II, ET-1 - Endothelin-1.
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BMC Neuroscience

ISSN: 1471-2202

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