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Table 1 Contractile responses to 5-CT, Ang II, and ET-1

From: Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway

    Sigmoidal curve Biphasic curve
  n K+ (mN) Emax (%) pEC50 Emax(1) (%) Emax(2) (%) pEC50(1) pEC50(2)
5-CT         
   Vehicle 5 6.87 ± 1.07 39.20 ± 12.09 6.92 ± 0.40     
   SB-386023 6 7.42 ± 1.10 25.13 ± 4.75 7.28 ± 0.31     
   SB-590885 6 5.45 ± 1.16 11.75 ± 3.43* 6.65 ± 0.25     
Ang II         
   Vehicle 6 7.16 ± 0.92 46.43 ± 6.78 10.11 ± 0.25     
   SB-386023 7 7.08 ± 0.95 26.20 ± 4.37 10.15 ± 0.23     
   SB-590885 7 5.88 ± 1.12 11.56 ± 2.72*** 9.45 ± 0.96     
ET-1         
   Vehicle 6 7.16 ± 0.92    36.71 ± 12.09 128.40 ± 6.91 11.74 ± 0.20 9.17 ± 0.18
   SB-386023 7 7.08 ± 0.95    25.60 ± 7.40 132.20 ± 8.46 11.73 ± 0.16 8.96 ± 0.20
   SB-590885 7 5.88 ± 1.12    7.44 ± 2.44* 147.4 ± 11.04 11.37 ± 0.20 9.07 ± 0.08
  1. Responses were characterized by Emax values, expressed as percent of 63.5 mM K+-induced contraction, and pEC50 values. Values are represented as mean ± s.e.m., with n representing the number of patients. Statistical analyses were performed using the non-parametric Kruskal-Wallis test and Dunn´s multiple comparison test. *P < 0.05, ***P < 0.001 compared with vehicle. 5-CT - 5-carboxamidotryptamine, Ang II - Angiotensin II, ET-1 - Endothelin-1.