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Table 1 APP+ vesicle formation in MND autopsies

From: Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: Implications for human motor neuron disease

CASE # AGE GENDER PM [h] PATHOLOGICAL DIAGNOSIS DEG. APP+ VESICLES VPS54 SEQ. ALTERATION
1 74 M 83 MND -3 + n.d.
2 49 M 32 MND -3 - None
3 58 M 37 MND -2 - n.d.
4 69 F 17 MND -3 + n.d.
5 48 M 25 MND -2 + None
6 81 F 30 MND -2 - None
7 55 M 39 MND -2 - None
8 72 F 6 MND -1 - n.d.
9 68 F 70 MND -3 + None
10 54 M 30 MND -1 - n.d.
11 51 F 24 MND -3 + None
12 54 M 95 MND -2 + n.d.
13 54 F ? MND Familial -3 - n.d.
14 56 M 79 MND Familial -2 - n.d.
15 89 F 54 PD -1 - None
16 85 F 9 PD -2 - None
17 61 M 65 Amyloid plaques 0 - n.d.
18 79 M 24 Mild ageing changes 0 - n.d.
19 80 M 48 changes consistent with ageing 0 - n.d.
20 40 M 40 Normal adult brain 0 - n.d.
21 57 M 26 Normal adult brain 0 - n.d.
22 87 F 21 Normal adult brain 0 - None
23 68 M 53 Normal adult brain 0 - n.d.
24 64 F 60 Normal adult brain 0 - n.d.
25 61 M 35 Normal adult brain 0 - n.d.
26 58 F 21 Mild ischemia 0 - None
27 68 M 40 Diffuse hypoxic damage 0 - n.d.
28 61 M 65 None given 0 - n.d.
  1. Legend: Histological assessment of human Motor neuron disease (MND) autopsies from spinal cord. Spinal cord sections were fixed in formalin after the post-mortem time indicated ("PM", in hours [h]) and later embedded in paraffin. The grades of Motor neuron degeneration were judged by Nissl staining and designated as 0 (no degeneration), -1 (single degenerating neurons), -2 (more than one degenerating motor neuron per ventral horn), -3 (groups of degenerating motor neurons). Note that in non-ALS brains including normal adult brain or other origins of neurodegeneration, APP+ vesicles have not been detected.