Physical Activity and Body Weight. General physical activity significantly decreased in the CMF group compared to the saline group during the treatment period but fatigue decreased once the drugs were discontinued (A). In contrast, no weight loss was seen in the CMF group during the treatment period (B). However, the CMF group failed to normally gain weight compared to the saline group although they remained healthy throughout the study and no overall reduction in food intake was observed. *p < 0.05.