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Table 2 Effect of 8 week SHS on rat cerebral artery contractions induced by K+, S6c and ET-1.

From: Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ETA receptors

Group

n

K+ (mN)

S6c

ET-1

   

Emax (% of K+)

pEC50

Emax (% of K+)

pEC50

Fresh air

10

5.7 ± 0.42

8.7 ± 0.5

9.32 ± 0.13

124 ± 9

8.86 ± 0.15

SHS

9

6.1 ± 0.53

9.5 ± 0.6

9.54 ± 0.19

160 ± 11*

8.97 ± 0.11

SHS+GW

8

6.3 ± 0.58

9.7 ± 0.9

9.37 ± 0.14

132 ± 15

8.77 ± 0.13

  1. The cerebral arteries were from groups of fresh air, SHS and SHS treatment with GW5074 for 8 weeks. K+-induced responses were expressed as absolute values of contraction (mN). S6c and ET-1-induced responses were expressed as percentage of K+-induced contraction. *P < 0.05 versus fresh air group. Emax, maximal contraction; pEC50, negative logarithm of the concentration that produces 50% of the maximal contractile effect; SHS, secondhand smoke exposure; GW, GW5074 (0.5 mg/kg).
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BMC Neuroscience

ISSN: 1471-2202

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