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Table 2 Effect of 8 week SHS on rat cerebral artery contractions induced by K+, S6c and ET-1.

From: Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ETA receptors

Group n K+ (mN) S6c ET-1
    Emax (% of K+) pEC50 Emax (% of K+) pEC50
Fresh air 10 5.7 ± 0.42 8.7 ± 0.5 9.32 ± 0.13 124 ± 9 8.86 ± 0.15
SHS 9 6.1 ± 0.53 9.5 ± 0.6 9.54 ± 0.19 160 ± 11* 8.97 ± 0.11
SHS+GW 8 6.3 ± 0.58 9.7 ± 0.9 9.37 ± 0.14 132 ± 15 8.77 ± 0.13
  1. The cerebral arteries were from groups of fresh air, SHS and SHS treatment with GW5074 for 8 weeks. K+-induced responses were expressed as absolute values of contraction (mN). S6c and ET-1-induced responses were expressed as percentage of K+-induced contraction. *P < 0.05 versus fresh air group. Emax, maximal contraction; pEC50, negative logarithm of the concentration that produces 50% of the maximal contractile effect; SHS, secondhand smoke exposure; GW, GW5074 (0.5 mg/kg).