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Table 1 Time course of SHS on rat cerebral artery contractions induced by K+, S6c and ET-1.

From: Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ETA receptors

Exposure time (week) Group n K+ (mN) S6c
(Emax % of K+)
ET-1
(Emax % of K+)
2 Fresh air 4 5.6 ± 0.58 8.5 ± 0.9 127 ± 14
  SHS 3 5.8 ± 0.63 8.3 ± 1.0 132 ± 15
4 Fresh air 4 5.4 ± 0.52 8.9 ± 1.1 131 ± 17
  SHS 4 6.2 ± 0.69 9.1 ± 1.3 136 ± 19
  1. The cerebral arteries were from groups of fresh air and SHS for 2 and 4 weeks. K+-induced responses were expressed as absolute values of contraction (mN). S6c and ET-1-induced responses were expressed as percentage of K+-induced contraction. Emax, maximal contraction; SHS, secondhand smoke exposure.