Targeted deletion
|
QACRG catalytic domain
|
QACRG catalytic domain
|
QACRG catalytic domain
|
Exon 3
|
or mutation site
|
Exons 5-6
|
Exons 5-6
|
C163S point mutation
| |
Phenotype
|
Survive on C57BL/6 background
|
Survive on C57BL/6 background
|
C3H background
|
Survive on C57BL/6 background
|
|
Smaller body size
|
Smaller body size
|
Smaller body size
|
Smaller body size
|
|
Progressive hearing loss
|
Progressive hearing loss
|
Hearing loss
|
Hearing loss
|
| |
Hyperactive
| |
Hyperactive
|
| |
Circling behavior
| |
Circling behavior
|
Cochlear histology
|
Hyperplasia of border cells
|
Loss of cochlear hair cells
|
Loss of cochlear hair cells
|
Loss of cochlear hair cells
|
|
Degeneration of cochlear hair cells, spiral ganglion cells
|
Loss of spiral ganglion cells
|
Loss of spiral ganglion cells
| |