Inner ear dysfunction in caspase-3 deficient mice

BMC Neuroscience

Table 1 Comparison of Casp3 mutant mice

	Casp3 KO mice	Casp3 KO mice	Melody ENU mutant	Casp3^ex3KO mice
	(Takahashi et al., 2001[7])	(Morishita et al., 2001[8])	(Parker et al., 2010[9])	(This study)
Targeted deletion	QACRG catalytic domain	QACRG catalytic domain	QACRG catalytic domain	Exon 3
or mutation site	Exons 5-6	Exons 5-6	C163S point mutation
Phenotype	Survive on C57BL/6 background	Survive on C57BL/6 background	C3H background	Survive on C57BL/6 background
	Smaller body size	Smaller body size	Smaller body size	Smaller body size
	Progressive hearing loss	Progressive hearing loss	Hearing loss	Hearing loss
		Hyperactive		Hyperactive
		Circling behavior		Circling behavior
Cochlear histology	Hyperplasia of border cells	Loss of cochlear hair cells	Loss of cochlear hair cells	Loss of cochlear hair cells
	Degeneration of cochlear hair cells, spiral ganglion cells	Loss of spiral ganglion cells	Loss of spiral ganglion cells

ISSN: 1471-2202