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Table 1 Comparison of Casp3 mutant mice

From: Inner ear dysfunction in caspase-3 deficient mice

  Casp3 KO mice Casp3 KO mice Melody ENU mutant Casp3ex3KO mice
  (Takahashi et al., 2001[7]) (Morishita et al., 2001[8]) (Parker et al., 2010[9]) (This study)
Targeted deletion QACRG catalytic domain QACRG catalytic domain QACRG catalytic domain Exon 3
or mutation site Exons 5-6 Exons 5-6 C163S point mutation  
Phenotype Survive on C57BL/6 background Survive on C57BL/6 background C3H background Survive on C57BL/6 background
  Smaller body size Smaller body size Smaller body size Smaller body size
  Progressive hearing loss Progressive hearing loss Hearing loss Hearing loss
   Hyperactive   Hyperactive
   Circling behavior   Circling behavior
Cochlear histology Hyperplasia of border cells Loss of cochlear hair cells Loss of cochlear hair cells Loss of cochlear hair cells
  Degeneration of cochlear hair cells, spiral ganglion cells Loss of spiral ganglion cells Loss of spiral ganglion cells  
  1. KO, knockout. ENU, N-ethyl-N-nitrosourea.