Table 1 Comparison of Casp3 mutant mice
| Â | Casp3 KO mice | Casp3 KO mice | Melody ENU mutant | Casp3ex3KO mice |
|---|---|---|---|---|
| Â | (Takahashi et al., 2001[7]) | (Morishita et al., 2001[8]) | (Parker et al., 2010[9]) | (This study) |
Targeted deletion | QACRG catalytic domain | QACRG catalytic domain | QACRG catalytic domain | Exon 3 |
or mutation site | Exons 5-6 | Exons 5-6 | C163S point mutation | Â |
Phenotype | Survive on C57BL/6 background | Survive on C57BL/6 background | C3H background | Survive on C57BL/6 background |
| Â | Smaller body size | Smaller body size | Smaller body size | Smaller body size |
| Â | Progressive hearing loss | Progressive hearing loss | Hearing loss | Hearing loss |
| Â | Â | Hyperactive | Â | Hyperactive |
| Â | Â | Circling behavior | Â | Circling behavior |
Cochlear histology | Hyperplasia of border cells | Loss of cochlear hair cells | Loss of cochlear hair cells | Loss of cochlear hair cells |
| Â | Degeneration of cochlear hair cells, spiral ganglion cells | Loss of spiral ganglion cells | Loss of spiral ganglion cells | Â |