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Learning and generation of temporal sequences in the neocortex

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The temporal structure of neuronal activity plays a fundamental role in brain function. In addition to the compelling structure found in birdsong, repeating temporal sequences have been experimentally observed in the mammalian neocortex, both at the levels of local field potentials and individual neurons.

The mechanisms underlying the learning and generation of temporal sequences are currently unknown. An attractive idea is that time-asymmetric Hebbian mechanisms capture the temporal structure of afferent signals by selectively strengthening the connections between sequentially activated neuronal populations. We explore some consequences of this idea using a simplified model of neocortex.

Our model uses excitatory and inhibitory firing rate variables, along with adaptation and time-asymmetric Hebbian plasticity to create a versatile pattern generator which can store and reconstruct input sequences. We study several related properties of this model, mainly: 1) the formation of intersecting and complex sequences, 2) how the structure in the connection matrix affects the dynamics of the system and the symmetries observed in the activity of the network, 3) pathological behaviors due to abnormalities in plasticity and inhibition; the possible relation with epilepsy.

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Correspondence to Sergio Verduzco-Flores.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Verduzco-Flores, S., Bodner, M. & Ermentrout, B. Learning and generation of temporal sequences in the neocortex. BMC Neurosci 11, P101 (2010) doi:10.1186/1471-2202-11-S1-P101

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Keywords

  • Firing Rate
  • Field Potential
  • Temporal Structure
  • Input Sequence
  • Neuronal Population