Figure 10

Microphotographies of n-Tyr immunoreactivity in the cortex and nuclei of rat cerebellum rostro-caudal sections. Panels A, E and G: adult rat. Panels B, C, D, F and H: old rat. n-Tyr immunoreactivity can be detected in the Purkinje cells (pc) of adult and old animals (A-D). In the aged animals, n-Tyr-IR glial cells (arrowheads) widely distributed within the white matter (wm) and the three layers of the cerebellar cortex are observed (B, C, F). Some glial cells (arrowheads) showing immunoreactive processes (arrow) surrounding blood vessels (v) were also present in old animals (F). In the adult individuals, n-Tyr-IR glial cells (arrowheads) are detected as well (A, E). Detail of retracted Purkinje cell (pc) apical processes (asterisk) in the aged rat cerebellum (D). Highly marked neurons (nr) and glial cells (arrowheads) are observed in the fastigial nucleus (fg) of old rats (H) but not in adult rats (G). g: granular layer; m: molecular layer; p: Purkinje cells layer. Scale bars: A and B, 200 μm; C-F, 20 μm; G and H, 100 μm.