Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

BMC Neuroscience

Table 1 Curcumin neutralizes αS-induced cytotoxicity in SH-SY5Y cells

Sample	LDH (% control)	SE	p-value	Viability (% control)	SE	p-value
Tris buffer (control)	100	2.4	NA	100	4.3	NA
αS	121.5	3.5	0.005^a	67.9	1.9	0.004^a
αS + curcumin	99.7	5.3	0.018^b	89.1	4.1	0.008^b
Curcumin	99.3	4.9	0.936	96.8	5.6	0.501

Cytotoxicity was measured using LDH assay and cell viability was determined using resazurin reduction assay. SH-SY5Y cells were incubated with Tris buffer (control), αS, αS+curcumin and curcumin for 48 hr before analysis. The LDH release and cell viability were expressed as a percentage of the untreated samples. Data was reported as mean ± SE, n = 4. ^acompared with the control; ^bcompared with αS-treated samples.

ISSN: 1471-2202