Figure 4From: Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner earImmunoreactivity for VEGF in the spiral ganglion cells. Little or no staining was detected in the spiral ganglion cells of the untreated samples (A; Normal). VEGF expression (green) was weakly detected in a few spiral ganglion neurons in samples treated with physiological saline (B; Saline) and those treated with 0.1% DMSO (D; DMSO). VEGF expression was strongly detected in a large number of the spiral ganglion neurons treated with EP2 agonist (C; EP2 agonist) or EP4 agonist (E; EP4 agonist). Nuclei were labeled with DAPI. The specimens were viewed with 63× oil objective. Scale bar = 200 μm.Back to article page