Figure 7

Open field and fear conditioning defects in Survivin^Camcremice. (A) Open field test data are provided, with representative paths of control (wt) and Survivin^Camcre(ko) mice. (B) Contextual and auditory-cued fear conditioning in control and Survivin^Camcremice. Freezing times in pre-US, post-US and pre-CS trials were not different between control and Survivin^Camcremice. Survivin^Camcremice showed significantly less freezing responses as compared to controls during both the context and the auditory cue (CS) trials. US: unconditioned stimulus, shock; CS: conditioned stimulus, auditory cue. Results in panel B are reflected as means + SEM, n = 12 mice per group. **P < 0.001.