SurvivinCamcremice exhibit increased seizure activity. (A) Scatter plot showing the maximum seizure score assigned to each experimental animal during a 2 hr observation period following KA administration. Seizure scores were significantly higher in the SurvivinCamcremice as compared to controls. Horizontal bars indicate the mean for each group. (B) KA (20 mg/kg ip) induced signficantly more severe seizure activity in SurvivinCamcremice as compared to controls, P < 0.001, n = 13-16 mice per group. (C, D) Representative NPY-stained coronal sections through the hippocampus of saline-treated control (wt) (C) and SurvivinCamcremice (ko) (D) reveals ectopic NPY expression by mossy fibers in SurvivinCamcremice (arrows in D). (E) Quantification of BrdU+ cells (1 day after BrdU injection) in the SGZ from saline and KA treated control and SurvivinCamcremice. The neurogenic response to KA was significantly dampened in SurvivinCamcremice as compared to controls, n = 4-5 mice per group. Results in panels B and E are reflected as means + SEM. **P < 0.001. Scale bars: C-D 500 μm.