Figure 7
From: Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro
Proposed model of neurite outgrowth pathway in postnatal SVZ/RMS-derived neurons. The PI3K catalyzes phosphorylation of PIP4,5 (PIP2) to produce PIP3,4,5 (PIP3), which in turn activates Akt1 and PKCζ. It is likely that Cdc42 is preferentially activated directly via PIP3 to PKCζ and for Rac1 preferential activation is via PIP3,4,5 and Akt1 to PKCζ. Akt1 can be also activated by other kinases.