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Figure 4 | BMC Neuroscience

Figure 4

From: Increased spinal prodynorphin gene expression in reinflammation-associated hyperalgesia after neonatal inflammatory insult

Figure 4

Quantification of proDYN mRNA-positive neurons using in situ hybridization in laminae I-II and laminae III-V of the dorsal horn 24 h after reinflammation with CFA injection into bilateral hind paws at postnatal time 6-8 weeks in the neonatal CFA group. A significant increase in the number of proDYN mRNA-positive neurons was found in laminae I-II of the left side that received a neonatal peripheral CFA insults compared to the right dorsal horn, which did not receive neonatal CFA insults (* P < 0.05). There was also an increase in the number of proDYN mRNA-positive neurons in laminae III-V of the neonatal CFA-treated side compared with the contralateral side; however, this difference was not significant.

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