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Figure 3 | BMC Neuroscience

Figure 3

From: Increased spinal prodynorphin gene expression in reinflammation-associated hyperalgesia after neonatal inflammatory insult

Figure 3

In situ hybridization study showing an upregulation of the proDYN mRNA in the dorsal horns after reinflammation. A low-magnification image shows neurons expressing spinal proDYN mRNA in the superficial and deeper laminae of the dorsal horn 24 h after reinflammation in the CFA group (A). A high-magnification image of Figure 3A shows a comparable increase in proDYN mRNA-positive neurons in laminae I-II of the dorsal horn ipsilateral (B) side that experienced neonatal peripheral inflammation compared with the contralateral side, which did not receive neonatal peripheral CFA insults (C). Scale bars: a, 200 μm; b and c, 100 μm

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