cAPPL sequence and comparison with other APP-like proteins. a) Partial nucleotide and deduced aminoacid sequence for cAPPL. The predicted transmembrane region is double underlined and a posible glycosilation signal is underlined in bold. Bases corresponding to degenerate primer regions in the sequencing or different in one of the three sequenced clones are highlighted in violet. b) General characteristics of APP family members. Large boxes represent the conserved extracellular (E1, E2) and cytoplasmic conserved regions (C). Yellow boxes are indicative of putative transmembrane domains. N-Glycosylation sites (NXS/T with X≠P) are indicated with balloons. Dark gray boxes indicate regions of absolute sequence identity used for degenerate primer design. c) Aminoacid sequence comparison. The regions of highest homology between human, C. elegans, Drosophila and Chasmagnathus are presented. Shaded and bold residues are identical, bold aminoacids represent conservative changes.