Figure 4
Bar graphs of T 2 relaxivity measured from parametric T 2 maps generated from T2W MRI scans acquired 3 weeks post-lesion from saline and lactacystin-injected animals. (A) No significant difference in T2 was observed in the striatum between saline and lactacystin-injected animals. By contrast, moderate, but significant reductions in T2 were observed in the ventral midbrain (C) and substantia nigra (E) of lactacystin-injected animals compared to saline controls. Example ROIs used to generate quantitative T2 data are shown for striatum in (B), ventral midbrain (D) and substantia nigra (F), respectively. Data shown are the ratio of T2 between the contralateral and ipsilateral hemispheres ± SEM for saline and lactacystin-injected animals, respectively. *p < 0.05; saline vs. lactacystin.