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Table 1 Levels of MMP-9 and TIMP-1 protein in the middle cerebral artery after MCAO and after treatment with the MEK1/2 inhibitor U0126 at 0, 6, and 12 hours post occlusion

From: Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat

Middle cerebral artery
  Control MCAO MCAO + U0126 - 0 h MCAO + U0126 - 6 h MCAO + U0126 - 12 h
MMP-9 (%) ± SEM 100 ± 3 198 ± 7** 114 ± 10§ 113 ± 8§ 144 ± 5
TIMP-1 (%) ± SEM 100 ± 5 191 ± 7** 137 ± 5 100 ± 4§§ 184 ± 19