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Table 2 Immunocytochemical quantification in the cerebellar cortex of groups A, B, C and D.

From: Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air)

Marker

Group A

Group B

Group C

Group D

SOD1

43.8 ± 1.2

(+24)*

73.6 ± 6

(+108)*

62.8 ± 1.5

(+78)*

35.3 ± 1.2

SOD2

62.8 ± 5.8

(+83)*

78.6 ± 6.7

(+129)*

36 ± 1.8

(+5)

34.2 ± 2.7

HO1

49.5 ± 2.6

(+115)*

54.2 ± 1.7

(+135)*

37 ± 1.4

(+61)*

23 ± 1.9

iNOS

53.2 ± 4.1

(+93)*

65.4 ± 5.3

(+138)*

59 ± 3.7

(+114)*

27.5 ± 2.5

nNOS

51.8 ± 6

(-13)

36.3 ± 4

(-61)*

52.3 ± 6

(-12)

59.2 ± 8

eNOS

79.5 ± 7

(+6)

80.3 ± 6

(+7)

73 ± 6

(-3)

75.3 ± 5

Nitrotyrosine

25.7 ± 4.3

(+109)*

31.8 ± 2.6

(+159)*

26.4 ± 3.9

(+115)*

12.3 ± 2.2

Neurofilaments

39.5 ± 4

(-61.71)*

35.6 ± 5.2

(-56)*

40 ± 6.2

(-62)*

64 ± 4

GFAP

64.6 ± 1.4

(+131)*

45.8 ± 1.4

(-7)

47.2 ± 1.9

(-4)

49.2 ± 2.2

Parvalbumin

44.5 ± 9.8

(-1.7)

37.8 ± 7.5

(-17)

44 ± 8.5

(-2.9)

45.3 ± 9.5

GAD

63 ± 5.2

(-20)*

60 ± 5.8

(-24)*

57.6 ± 4.6

(-27)*

79 ± 7.8

Calbindin

44 ± 12

(-10)

48 ± 12.5

(-2)

46.7 ± 12

(-5)

49 ± 13

Synapsin

31 ± 4

(-39)*

17.6 ± 3

(-65.5)*

42 ± 6.5

(-18)

51 ± 4.4

Ferritin-H

80 ± 5.6

(+1.3)

113 ± 5

(43)*

79.5 ± 1.9

(+0.6)

79 ± 3.6

  1. ± = standard error of the mean.
  2. () = % from the control. + = increased immunoreactivity, - = decreased immunoreactivity.
  3. Comparisons were made by one way ANOVA. Group D vs. group A, group D vs. group B and group D vs. group C. *Values were considered statistically significant when p values were ≤ 0.05.
  4. nns: non significant.
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BMC Neuroscience

ISSN: 1471-2202

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