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Table 2 Model Species and Initial Values

From: A mathematical model of aging-related and cortisol induced hippocampal dysfunction

Abbreviation Species Value*
AC Adrenal cortex 100
ACS Adrenal cells sink 35 pg/mL (Jacobi, Titze et al. 2001)
ACTH Adrenocorticotropic hormone 15 μg/dL (Jacobi, Titze et al. 2001)
Cort Cortisol 35
CRH Corticotropin-releasing hormone 0
CS Cortisol sink 100
DGF Denditic Growth Factors 0
DGFS Denditic Growth Factors Sink 100
ES External stress 0
GRA Active GR receptors 0
GRAS Active GR receptors sink 1.4 × 104 (Goncharuk, Van Heerikhuize et al. 2002)
HCS Hypothalamus secretory cells sink 0
HSC Hypothalamus secretory cells 100
HTA Hippocampus Tissue Area 100
HO Hippocampus output 0
HOS Hippocampus output sink 0
MRA Active MR receptors 0
MRAS Sink for MR active receptors 100
NBD Neuronal branching; Dendrites 0
NBDS Neuronal branching dendrites sink 100
NGF Neuronal Growth factors 100
NGFS Loss of neuronal growth factors 100
NPOP Population of neurons in the CA1 4.85 × 107 (Simic, Kostovic et al. 1997).
NPOPS Decline in neuronal population of cells 0
PSC Pituitary secretory cells 1.0*107 (Trouillas, Guigard et al. 1996)
PCS Pituitary secretory cell sink 0
Ue Exitatory synapses 100
Is# Synaptic current 100
Ui Inhibitory synapses 0
SISS Synaptic inhibitory spikes sink 100
V Synaptic output 100
TF Trophic Factors 100
TFS Trophic Factors Sink 0
TM Tissue mass 70 kg
  1. This table describes the algebraic abbreviations used throughout subsequent mathematical expressions used to describe cortisol synthesis by the HPA and saturation of hippocampal MR and GR receptors with respect to hippocampal activity and aging related atrophy. Values set to 100 are indicative of % activity based on the assumption that the physiological system was healthy at the initiation of the simulation. *Numerical values for neuronal populations etc were extracted from published human clinical studies where available.