A mathematical model of aging-related and cortisol induced hippocampal dysfunction

BMC Neuroscience

Table 2 Model Species and Initial Values

Abbreviation	Species	Value*
AC	Adrenal cortex	100
ACS	Adrenal cells sink	35 pg/mL (Jacobi, Titze et al. 2001)
ACTH	Adrenocorticotropic hormone	15 μg/dL (Jacobi, Titze et al. 2001)
Cort	Cortisol	35
CRH	Corticotropin-releasing hormone	0
CS	Cortisol sink	100
DGF	Denditic Growth Factors	0
DGFS	Denditic Growth Factors Sink	100
ES	External stress	0
GRA	Active GR receptors	0
GRAS	Active GR receptors sink	1.4 × 10⁴ (Goncharuk, Van Heerikhuize et al. 2002)
HCS	Hypothalamus secretory cells sink	0
HSC	Hypothalamus secretory cells	100
HTA	Hippocampus Tissue Area	100
HO	Hippocampus output	0
HOS	Hippocampus output sink	0
MRA	Active MR receptors	0
MRAS	Sink for MR active receptors	100
NBD	Neuronal branching; Dendrites	0
NBDS	Neuronal branching dendrites sink	100
NGF	Neuronal Growth factors	100
NGFS	Loss of neuronal growth factors	100
NPOP	Population of neurons in the CA1	4.85 × 10⁷ (Simic, Kostovic et al. 1997).
NPOPS	Decline in neuronal population of cells	0
PSC	Pituitary secretory cells	1.0*10⁷ (Trouillas, Guigard et al. 1996)
PCS	Pituitary secretory cell sink	0
Ue	Exitatory synapses	100
Is#	Synaptic current	100
Ui	Inhibitory synapses	0
SISS	Synaptic inhibitory spikes sink	100
V	Synaptic output	100
TF	Trophic Factors	100
TFS	Trophic Factors Sink	0
TM	Tissue mass	70 kg

This table describes the algebraic abbreviations used throughout subsequent mathematical expressions used to describe cortisol synthesis by the HPA and saturation of hippocampal MR and GR receptors with respect to hippocampal activity and aging related atrophy. Values set to 100 are indicative of % activity based on the assumption that the physiological system was healthy at the initiation of the simulation. *Numerical values for neuronal populations etc were extracted from published human clinical studies where available.

ISSN: 1471-2202