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Figure 5 | BMC Neuroscience

Figure 5

From: Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrus

Figure 5

Suggested pathways through which Src kinase regulates cell proliferation in the DG after ischemia. Transient global ischemia triggered sustained activation of Src kinase by intracellular Ca2+ influx via NMDA and L-VGCC or released from ER and mitochondria. Subsequently, activated Src induced continuous phosphorylation of ERK through direct phosphorylation of Raf-1 at its Tyr 340/341, and in turn, was translocated from the cytosol to the nucleus where it regulated transcription via CREB and some genes relating to cell proliferation expression.

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