Inhibiting the activation of Src kinase by SU6656 down-regulate Raf (Y340)/ERK/CREB cascade after ischemia- reperfusion. Samples were used as in Fig. 1. (A) Raf phosphorylation at Tyr340/341. (B) ERK phosphorylation at Thr202/Tyr204. (C) CREB phosphorylation at Ser133. Data are expressed as mean ± S.D. (n = 4/group) *P < 0.05 vs. sham group, #P < 0.05 vs. respective reperfusion group.