Experimental design, words learned per week and RBMT-E recall scores for Groups A and B. A) Schematic of crossover experimental design: Group A learned from Week 1 to Week 6; Group B learned from Week 6 to Week 12. Both groups completed memory test batteries at Week 0, 6 and 12, and all consenting participants were scanned with MRS at Weeks 6 and 12. B&C) Weekly words learned per participant for Group A and Group B (three non-compliant participants removed) demonstrating significantly larger mean improvement across the six weeks for Group A. D) Immediate Recall of the short story subtest of the RBMT. Group A (heavy line, filled squares) showed a significant improvement in recall relative to Group B (thin line, empty squares) at Battery 3, and a significant within-groups improvement relative to Battery 1 and 2. Horizontal bars represent 6-week learning blocks for Group A (grey bar) and Group B (white bar).