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Figure 3 | BMC Neuroscience

Figure 3

From: Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities

Figure 3

Wildtype and PEA-15 Knockout mice did not differ significantly in acquisition during non-spatial learning tasks. (A) Average number of errors committed during acquisition of the Odor Discrimination task are depicted. (B) Latencies to find the reward in the Odor Discrimination task are shown. (C) Average number of errors committed during acquisition in the Lashley 3 Maze is shown. (D) Latencies to transverse the maze and find the reward in the Lashley 3 Maze are depicted. (E) Passive avoidance is measured as step-down latencies before (pre) and after (post) training in the Passive Avoidance task. Four mice, two from each group, were removed from this test because their pre-training latencies did not meet criteria: that is they did not step down in the maximum 300 seconds allowed during training. (F) Conditioned Fear is expressed as a ratio of the latency to make 25 licks before (pre) and after (post) CS (tone) presentation subsequent to associative fear conditioning. One mouse was not included in the fear conditioning data because of an apparatus recording failure. Data are shown as mean values ± SEM; n values are indicated.

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