Volume 8 Supplement 2
NeuroBlast: a 3D spatial homology search tool for gene expression
© Ng et al; licensee BioMed Central Ltd. 2007
Published: 6 July 2007
Finding genes with a similar spatial expression pattern as a known gene could potentially reveal novel or unknown genes involved in similar processes or pathways. The Allen Brain Atlas (ABA)  is an effort to produce a genome-wide mapping of the gene expression in the adult C57BL/6J mouse brain. To date, more than 21,000 genes have been assayed using a high-throughput in situ hybridization (ISH) platform and the resulting image data is publicly available at http://brain-map.org. A major goal of the ABA project is to employ image analysis techniques to search the ABA data for particular expression patterns such as spatial gene expression homologues.
We presented the functionality of NeuroBlast, a spatial search tool for finding genes with similar expression patterns within the ABA dataset. Preliminary testing of our pilot study has demonstrated efficacy of searches over different expression patterns and domain of interest. A comprehensive version of NeuroBlast spanning the entire ABA data will be publicly available in 2007.
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- Ng L, Pathak S, Kuan L, Lau C, Dong HW, Sodt A, Dang C, Avants B, Yushkevich P, Gee J, Haynor D, Lein E, Jones A, Hawrylycz M: Genomic Scale Neuroinformatics for 3-D Gene Expression Mapping. IEEE/ACM Transaction on Computational Biology and Bioinformatics. 2007Google Scholar
This article is published under license to BioMed Central Ltd.