Figure 4

TBS-induced LTP in hippocampal slices from C57 mice recorded by 8 × 8 3D MEAs. A) Summary LTP data obtained in simultaneous recordings from proximal, medial and distal locations in stratum radiatum in 11 slices from C57 mice. B) Comparative changes of fEPSPs recorded from three different locations in SR before and 60 min after induction of LTP by three trains of TBS. Ratios of post- to pre-TBS fEPSP amplitudes are plotted against corresponding stimulus strengths. Data from two lowest stimulation strengths, 100 and 500 mV are omitted as the often produced zero or a very small response (< 100 μV). Note that the post/pre-LTP ratio is always larger in proximal compared to medial region of SR (Bonferroni/Dunn's post hoc test: * – P < 0.01; ** – P < 0.001; *** – P < 0.0001). Only a half of the S.D. error bar is shown for clarity.