Volume 13 Supplement 1

Twenty First Annual Computational Neuroscience Meeting: CNS*2012

Open Access

A minimal model for a slow pacemaking neuron

BMC Neuroscience201213(Suppl 1):P101

DOI: 10.1186/1471-2202-13-S1-P101

Published: 16 July 2012

We have constructed a phenomenological model for slow pacemaking neurons. These are neurons that generate very regular periodic oscillations of the membrane potential. The examples of these neurons are serotonin-containing neurons from the raphe nuclei, noradrenergic neurons located in the pontine nucleus locus coeruleus (LC) and dopaminergic neurons from the substantia nigra pars compacta. Many of these neurons also differentially respond to various types of stimulation. In particular, stimulation by injecting a current into the cell body (applied somatic depolarization) is expected to elicit bursting similar to stimulation by inputs from other neurons (synaptic currents), but it does not.

We have separated the most important property of the neuron that allows for the differential responses (see Fig. 1). Our model is based on FitzHugh-Nagumo (FHN) oscillator and implements a nonlinearity introduced by a current that depends on an ion concentration. The nonlinearity is crucial for such differentiation. We have explicitly shown that when the nonlinear activation function is replaced by a linear dependence, the model responds similarly to all stimuli and shows very little frequency variation. These are the properties of the classical FHN oscillator. Thus, the new nonlinear dependence allows for differentiating responses to various stimuli.
https://static-content.springer.com/image/art%3A10.1186%2F1471-2202-13-S1-P101/MediaObjects/12868_2012_Article_2638_Fig1_HTML.jpg
Figure 1

The NMDAR activation elevates the frequency, while the applied depolarization blocks oscillations. The voltage time-series are shown in response to square pulses of the applied depolarization (A) and NMDAR activation (B).

In the DA neuron, an SK-type Ca2+-dependent K+ current provides the necessary nonlinearity. Presumably, the same current works in serotonergic neurons. No data is available for other neurons, and the SK current may not be the only current that differentiates the responses. The mechanism works for other currents with a sigmoidal activation function. In fact, any function that starts flat and then sharply increases its slope works. The saturation part of the sigmoidal dependence is not necessary for the frequency responses. The current may depend on ion concentration, on the voltage, or on both variables. This further expands the applicability of our results to neurons expressing various currents. Therefore, in a wide class of neurons, the nonlinearity of a conductance will cause distinct responses to stimuli.

Declarations

Acknowledgements

The work was supported by the National Science Foundation grant DMS-0817717.

Authors’ Affiliations

(1)
Department of Mathematical Sciences and Center for Mathematical Biosciences, Indiana University Purdue University Indianapolis
(2)
Nonlinear dynamics department, Institute of Applied Physics, RAS

Copyright

© Kuznetsov and Zakharov; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement