Increased cerebral blood flow in the right frontal lobe area during sleep precedes self-awakening in humans
© Aritake et al.; licensee BioMed Central Ltd. 2012
Received: 30 September 2012
Accepted: 11 December 2012
Published: 21 December 2012
Some people can subconsciously wake up naturally (self-awakening) at a desired/planned time without external time stimuli. However, the underlying mechanism regulating this ability remains to be elucidated. This study sought to examine the relationship between hemodynamic changes in oxyhemoglobin (oxy-Hb) level in the prefrontal cortex and sleep structures during sleep in subjects instructed to self-awaken.
Fifteen healthy right-handed male volunteers with regular sleep habits participated in a consecutive two-night crossover study. The subjects were instructed to wake up at a specified time (“request” condition) or instructed to sleep until the morning but forced to wake up at 03:00 without prior notice (“surprise” condition). Those who awoke within ± 30 min of the planned waking time were defined as those who succeeded in self-awakening (“success” group). Seven subjects succeeded in self-awakening and eight failed.
No significant differences were observed in the amounts of sleep in each stage between conditions or between groups. On the “request” night, an increase in oxy-Hb level in the right prefrontal cortex and a decrease in δ power were observed in the “success” group around 30 min before self-awakening, whereas no such changes were observed in the “failure” group. On the “surprise” night, no significant changes were observed in oxy-Hb level or δ power in either group.
These findings demonstrate a correlation between self-awakening and a pre-awakening increase in hemodynamic activation in the right prefrontal cortex, suggesting the structure’s contribution to time estimation ability.
KeywordsTime estimation ability Self-awakening Sleep Cognitive science Prefrontal cortex Insomnia
We are often able to wake up spontaneously at a desired or planned time or to subconsciously estimate time elapsed during sleep without receiving external time stimuli such as from an alarm clock. This phenomenon is referred to as self-awakening [1–5] or anticipated sleep termination , and it is believed to be achieved by time estimation ability (TEA) , which is exercised even during sleep [8, 9]. A previous study reported that more than half of healthy adults believe that they are able to wake up by themselves during habitual sleep with an accuracy (i.e., difference between planned and actual wake up time) of ± 10 min .
Previous studies have identified several factors related to TEA during sleep, including an increased adrenocorticotropic hormone (ACTH) level observed before awakening , recurrent semi-awakening during sleep [11, 12], differences in preceding sleep structures [13, 14], diurnal fluctuation [15, 16], and psychological motivation [3, 17]. However, the brain region responsible for TEA has not been identified. Meanwhile, considerable information has been obtained regarding the neurological basis of TEA while awake [18–21]. The basal nuclei (corpus striatum), cerebellum, and prefrontal cortex have been shown to contribute to TEA in the order of seconds to minutes, and each of these three regions plays a different role. The cerebellum processes mainly timing information [22–24], the basal nuclei, in particular the corpus striatum, functions as a core timer [25–27], and the prefrontal cortex assists the basal nuclei in controlling timer rate, attention allocation, and temporal memory processing [26, 28–30]. Despite the possible contributions of these brain regions and the interval timer system to TEA during sleep, no study has continuously monitored the activity of these regions during the course of natural sleep. Thus, the neurological basis of TEA during sleep remains to be elucidated.
Several recent studies have shown changes in cerebral hemodynamics during sleep with near infrared spectroscopy (NIRS) [31–35]. One study showed a decrease in oxy-Hb levels of 5–10% from baseline (before sleep onset) during the first 60 min of sleep [32, 33]. This technique has the potential to elucidate specific hemodynamic change during self-awakening. The objective of this study was to determine whether the prefrontal cortex mediates self-awakening by: 1) setting two night conditions (“request”, where subjects were instructed at bedtime to wake up 3 h after lights out, earlier than the regular wake time; and “surprise”, where subjects were instructed to sleep for 8 h after lights out but forced to wake up 3 h after lights out without prior notice); and 2) measuring hemodynamic changes to the prefrontal cortex over time by multi-channel NIRS while simultaneously measuring sleep structures by polysomnography (PSG) during the first 3 h after lights out.
Fifteen healthy, right-handed male volunteers (age 22.1 ± 0.7 years (mean ± SD)) with regular sleep habits participated in the consecutive two-night, single-blind, crossover conditions (“request” and “surprise”). All subjects provided written informed consent after being informed of the possible risks and details of the study. A physician and a psychiatrist examined the subjects and found that no subjects suffered from a neurological or psychiatric disorder or had a history of psychoactive drug use. Subjects were instructed to maintain a regular sleep-wake schedule, record their sleep patterns in a sleep log, and abstain from caffeine, nicotine, and alcohol for 1 week prior to the experiment. All subjects wore a wrist activity recorder (Actiwatch-L, Mini-Mitter Co., Inc. Bend, OR) for 1 week prior to the experiment. Sleep onset and offset times were determined using Actiware Sleep software (V3. 2 Mini-Mitter Co., Inc.). Data recorded in the sleep logs together with sleep onset and offset times were used to confirm regular sleep-wake schedules. The study protocol was approved by the Ethics Committee of the Institutional Review Board of the National Center of Neurology and Psychiatry, Japan.
Simultaneous measurement of PSG and NIRS was performed throughout the sleep period, which was defined as the period from sleep onset to the designated wake time defined for each condition. PSG comprised electroencephalography (EEG; Fp1-A2, Fp2-A1, F3-A2, F4-A2, C3-A2, C4-A1, O1-A2, and O2-A1) in accordance with the 10–20 electrode system, electrooculography (EOG; left-A2 and right-A1), chin surface electromyography (chin-EMG), and electrocardiography (ECG). PSG data were obtained continuously during each experiment, digitalized at 500 Hz, and stored in a digital EEG system (Comet, Grass Technologies, Astro-Med, Inc., RI). The high cut and low cut filters were set at 60 Hz (except chin-EMG at 120 Hz) and 0.5 Hz, respectively.
NIRS of the human brain is a relatively flexible technique for measuring hemodynamic changes on the basis of differences in the absorbance of harmless near-infrared light between oxyhemoglobin (oxy-Hb) and deoxyhemoglobin (deoxy-Hb), and NIRS has been used to elucidate the physiological mechanisms of the blood oxygen level-dependent response [36–42]. Previous studies showed that NIRS signals correlate strongly with functional magnetic resonance imaging (fMRI) measurements [42, 43].
The coefficients in equations (1), (2), and (3) are coefficients of absorption at corresponding wavelengths. Determining changes in Hb levels with the modified Beer-Lambert Law depends on DPF, but optical pathlengths differ among individuals and depend on the position within the brain. Thus, oxy-Hb values measured by the OMM-3000 system show relative change in concentration, as opposed to absolute Hb concentration.
NIRS data could not be obtained from 4 of 15 subjects due to displacement of light-producing optrodes during sleep. Evaluation of sleep structures was made for 15 subjects while analysis of sleep structures in relation to oxy-Hb was performed for the 11 subjects with available NIRS data.
PSG data obtained over a period of about 3 h were scored for 30-s epoch periods according to standard criteria . The amount of stage W, stage 1, stage 2, stage 3+4, and stage REM sleep, as well as sleep latency, wake after sleep onset (WASO), and arousal index [35, 50] for total sleep time were calculated for all PSG recordings. Slow-wave sleep was calculated as the sum of stage 3 and stage 4 sleep. The frequency of body movement during sleep was determined by viewing a monitor and EEG waveforms in real-time. For more detailed analysis of sleep structures, power spectral analysis using fast Fourier transform (FFT) as a parameter of brain activity at the cortical level was also examined with Sleep Sign (Kissei Comtec, Nagano, Japan). The EEG power (delta: 0.5–4 Hz; theta: 4–8 Hz; alpha: 8–13 Hz, and sigma: 13–15 Hz) of F3-A2 and F4-A1 was obtained by FFT analysis of 2048 data-points (8 × 4.096-s sequences) tapered by a Hanning window. Since the eight sequences are longer than the visual epoch definitions for sleep staging, both sides of each sequence overlapped by 0.39 s. FFT values for each sequence were summed to obtain the value of EEG power per epoch. Epochs containing artifacts were visually identified and excluded from the analysis.
We focused on changes of oxy-Hb in the 60- to 30-min period before self-awakening, since previous study demonstrated increases in adrenocorticotropic hormone levels during this period . NIRS analysis on the “request” night was performed using data obtained from each subject during the final 30 min before self-awakening. On the “surprise” night, data obtained during the same period as that on the “request” night were used for analysis. NIRS data obtained from multiple analyzable channels every 200 ms were averaged every 30 s in line with PSG analysis to calculate Hb levels after excluding visible artifacts. A 0.02–1 Hz band pass filter was applied to individual data to remove artifacts caused by high-frequency instrument noise and low-frequency drift in oxy-Hb and deoxy-Hb signals in the fNIRS system. Since oxy-Hb level determined by NIRS is the most sensitive and representative optimal indicator of regional hemodynamic changes, we used this parameter in our analysis [32, 36, 51]. For the analysis of each right and left FC (rPFC and lPFC) region, we averaged the channels separately for each side (right and left) and region (rPFC region: 14, 15, 19, 20, 23, 24, 28, and 29; and lPFC region: 17, 18, 21, 22, 26, 27, 30, and 31).
To determine the effect of the order of each experimental condition on sleep duration during each PSG period, we compared the nocturnal duration of each sleep stage between the groups under each experimental condition using two-way measures ANOVA. We also analyzed the rate of oxy-Hb changes between the groups under the each experimental condition using two-way ANOVA (experimental condition × group). To compare fluctuations in oxy-Hb levels, individual sleep structures, and EEG power with time between the groups under each experimental condition, three-way (1 between-subjects factor and 2 within-subjects factors) repeated measures ANOVA (experimental condition × results group × time course) was performed. If significant interactions were obtained, planned follow-up ANOVA and post-hoc analysis were subsequently conducted to verify our assumption that changes in hemodynamics and EEG power in the prefrontal cortex area mediates self-awakening. SPSS ver. 18.0 (IBM, Cary, NC) was used for all statistical analysis. Results are expressed as mean and standard error values. Significance was set at p<0.05.
Self-awakening success and failure
In this study, 7 of 15 subjects succeeded in waking up at the predetermined time (03:00) under the “request” condition.
Sleep structures over 3 h and final 30 min
F [1, 13] (p-value)
F [1, 13] (p-value)
14.14 ± 13.70
19.79 ± 11.10
38.31 ± 12.82
26.00 ± 10.38
7.86 ± 2.62
6.29 ± 3.83
11.81 ± 2.45
16.94 ± 3.58
52.86 ± 10.69
43.14 ± 7.53
55.56 ± 10.00
69.06 ± 7.05
71.00 ± 12.67
58.57 ± 11.88
51.38 ± 11.85
50.63 ± 11.12
15.79 ± 5.19
14.00 ± 5.23
22.31 ± 4.85
9.13 ± 4.89
147.50 ± 17.29
122.00 ± 12.83
141.06 ± 16.17
145.75 ± 12.01
6.14 ± 2.27
3.29 ± 1.19
4.50 ± 2.12
4.00 ± 1.11
14.29 ± 15.14
16.86 ± 11.69
36.38 ± 14.16
24.25 ± 10.94
Arousal Index (h)
7.09 ± 1.98
9.01 ± 2.14
6.61 ± 1.83
7.71 ± 1.98
Number of Movements
6.33 ± 2.36
6.17 ± 2.08
7.86 ± 2.19
5.71 ± 1.92
Final 30 min
3.07 ± 1.09
4.43 ± 1.98
4.13 ± 2.04
8.88 ± 3.09
1.57 ± 0.95
0.93 ± 0.37
0.56 ± 0.29
2.50 ± 1.60
5.14 ± 2.06
12.79 ± 3.52
7.69 ± 2.88
11.31 ± 3.99
9.93 ± 4.25
9.00 ± 2.84
7.38 ± 4.07
3.19 ± 2.45
3.71 ± 2.52
0.50 ± 0.36
7.88 ± 3.81
4.13 ± 3.59
20.36 ± 4.15
23.21 ± 4.13
23.50 ± 4.15
21.13 ± 4.60
Thirty minutes before waking
Temporal changes in oxy−Hb levels in the PFC region
For oxy-Hb changes over 30 min in the rPFC area, a significant interaction of condition × group was obtained (F(1,9) = 3.513, p = 0.034) (Figure 4B-1, B-3). Under the “request” condition, the additional post-hoc test revealed that the rate of oxy-Hb change in the “success” group increased significantly more than in the “failure” group (F(1,9) = 7.768, p = 0.021), but not under the “surprise” condition (F(1,9) = 0.668, p = 0.435). Meanwhile, in the lPFC area, no difference in oxy-Hb change was observed (condition: F(1,9) = 0.275, p = 0.021; group: F(1,9) = 0.287, p = 0.605; interaction: F(1,9) = 2.183, p = 0.174) (Figure 4B-2, B-4).
Temporal changes in sleep structures
Two-way ANOVA revealed a significant interaction of time course × group under the “request” condition (interaction: F(5,45) = 3.037, p = 0.019; time course: F(5,45) = 0.494, p = 0.779; group: F(1,9) = 1.833, p = 0.209), but not under the “surprise” condition (interaction: F(5,45) = 1.134, p = 0.356; time course: F(5,45) = 0.867, p = 0.511; group: F(1,9) = 0.902, p = 0.367). Moreover, additional one-way ANOVA confirmed a significant increase in REM stage sleep in the “success” group with time under the “request” condition (time course: F(5,45) = 2.739, p = 0.043). Fluctuations of values in other sleep stages did not differ between condition or group.
Temporal changes in δ power
Figure 4-C shows changes in δ power in the lPFC and rPFC area during the final 30 min of sleep under each condition. In the rPFC region, three-way ANOVA showed a significant interaction of time course × group (F(5,45)=3.426, p=0.010). Follow-up one-way ANOVA revealed that δ power decreased significantly with time in the “success” group (F(5,45) = 3.113, p = 0.031), but not in the “failure” group (F(5,45) = 0.485, p = 0.784) (Figure 4C-1, C-3). In the lPFC region, three-way ANOVA showed no significant difference with time between conditions and groups (condition: F(1,45) = 0.001, p = 0.972; time course: F(1,45) = 1.739, p = 0.145; group: F(5,45) = 0.014, p = 0.908) or interaction (p ≥ 0.05 for all) (Figure 4C-2, C–4).
We examined changes in oxy-Hb levels during sleep as well as sleep depth and amount over time until a planned wake time under the “request” and “surprise” conditions by simultaneously recording NIRS and PSG data. The results revealed that under the “request” condition, an increase in the oxy-Hb level in the right prefrontal region and a rapid decrease in δ power occurred during the final 30 min of sleep in subjects who succeeded in self-awakening, whereas no changes were observed in these three parameters in subjects who failed to self-awaken. Under the “surprise” night condition, no significant changes were observed in these parameters during the final 30 min of sleep in either group.
Success rate for self-awakening
Seven of the 15 subjects succeeded in self-awakening. A previous telephone survey involving 300 subjects showed that more than half of the subjects were able to wake up naturally without an alarm clock . Hall and Brush tested whether subjects could wake up at a predetermined time on 50–100 nights and reported that about 70% were able to wake up almost exactly at the planned time [52, 53]. The self-awakening success rate in the present study is almost identical to that in previous studies.
Sleep structures preceding self-awakening
Although the neurological mechanism mediating self-awakening has not been clarified, it has been postulated that strong motivation toward self-awakening and resulting psychological strain reduces slow-wave sleep and increases shallow sleep, resulting in a lowered arousal threshold . Previous studies of sleep structures preceding self-awakening have yielded discrepant results; some showed a decrease in sleep depth [1, 54], while others showed no change . In the present study, assessment of sleep structures over the entire period between lights out and self-awakening showed no significant difference between the “request” and “surprise” nights. Meanwhile, the analysis results of sleep structures immediately before self-awakening and those of power analysis had several important implications. First, it should be noted that subjects who succeeded in self-awakening showed an increase in REM sleep over time during the final 30 min of sleep on the “request” night. However, the total amount of REM sleep during the period did not differ between conditions, and no such increase was observed in subjects who failed. Since REM sleep tends to occur at around 3 h after lights out—in other words, at the planned wake time—it is not surprising that REM sleep occurred during the final 30 min before self-awakening. Nevertheless, the fact that increased REM sleep was observed just before self-awakening in the “success” group under the “request” condition, but not under the “surprise” condition, supports the contention that increased REM sleep facilitates successful self-awakening [10, 13]. Second, it should be noted that a rapid decrease in δ power was also observed in the same area during the final 30 min of sleep in the “success” group under the “request” condition. This suggests that the rapid decrease in δ power around the planned time of self-awakening and the associated reciprocal increase in REM sleep may contribute to successful self-awakening.
Mechanism and localization of self-awakening
Subjects who succeeded in self-awakening showed an increase in oxy-Hb level in the right prefrontal region before self-awakening on the “request” night, which appears to reflect increased blood flow in the region. However, no significant differences were seen between groups for frequency of body movement, duration of each sleep stage, WASO, or total sleep time during the same period. It is thus unlikely that the observed increase in oxy-Hb level before self-awakening was caused by a change in the oxy-Hb level in association with coarse fluctuation of sleep structures or body movement. Subjects who succeeded in self-awakening showed decreased δ power and increased REM sleep during the final 30 min of sleep on the “request” night. It is likely that these changes in sleep structures secondarily or simultaneously led to a change in local blood flow in the prefrontal region . It is therefore reasonable to assume that increased blood flow in the prefrontal region resulted in self-awakening and the consequent arousal reaction. However, it remains unclear in our study why the blood flow increased significantly in the right but not the left prefrontal region.
It has been suggested that self-awakening is achieved by some kind of drive related to time recognition during sleep . The present findings support this contention indirectly. At least in the awake state, the basal nuclei (corpus striatum), cerebellum, and right prefrontal region have been shown to contribute to TEA [24, 26, 27]. The right prefrontal region, in which increased oxy-Hb levels were observed, is a region that showed increased blood flow in awake subjects during a time recognition test [30, 56], suggesting the contribution of increased blood flow in this region to successful self-awakening. However, the kind of physiological factors that trigger the increase in REM sleep or blood flow in the right prefrontal region during the 30 min before awakening in the present study remain unclear. Born et al. observed an increased ACTH level about 1 h prior to anticipated sleep termination . Positron emission tomography (PET) studies that have examined the correlation between cerebral blood flow, ACTH, and cortisol levels while awake have demonstrated that increased secretion of ACTH and cortisol correlates with increased blood flow [57–60]. Subjects in the present study who succeeded in self-awakening might also have had increased the activity of the hypothalamic-pituitary-adrenal axis before self-awakening.
The present findings suggest the involvement of pre-awake activation of the right prefrontal region in self-awakening. The effect of heart rate and peripheral vasodilation on cerebral blood flow is important when interpreting the present data. Such factors are expected to have various effects on the measured responses under different conditions (“request” versus “surprise”) and in different groups (“success” versus “failure”). Therefore, it is likely that heart rate and peripheral vasodilation played specific roles in the “success” group under the “request” condition. In addition, the sample population was relatively small, due to highly complex procedures involving spontaneous PSG and NIRS over the period of 3 h during sleep. Findings of this study need to be confirmed by other methods such as PET and fMRI. Once confirmed, further studies using techniques such as simultaneous measurement of fMRI and sleep EEG are needed to determine whether the deep brain regions, which are considered to be related to TEA and include the basal nuclei (striatum) and cerebellum, are involved in achieving self-awakening. Moreover, it will be necessary to elucidate whether TEA in the order of hours during sleep occurs in the same manner as TEA in the order of seconds to minutes. From the clinical viewpoint, patients who repeatedly experience sleep state misperception/paradoxical insomnia [61–63], waking after sleep onset, or waking in the early morning may have excessive and persistent activation of the right prefrontal region, which is caused by undefined mechanisms during sleep. Thus, elucidation of the neural mechanism of self-awakening should contribute to elucidating the pathophysiology of such difficult-to-treat insomnia symptoms.
Our present findings demonstrate a correlation between self-awakening and a pre-awakening increase in hemodynamic activation in the right prefrontal cortex, suggesting the structure’s contribution to time estimation ability.
We thank Masao Inoue for help with the NIRS analysis. We also thank Yujiro Taguchi and Sayaka Kohtoh for help with the FFT analysis. This study was supported in part by the Strategic Research Program for Brain Sciences from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Understanding of molecular and environmental bases for brain health) and the Research Grant for Nervous and Mental Disorders (11–3), a Health Science Grant (15130301) from the Ministry of Health, Labor and Welfare of Japan, a Grant-in-aid for Scientific Research (19790185). All authors declare no conflicts of interest associated with this study.
- Zung WW, Wilson WP: Time estimation during sleep. Biol Psychiatry. 1971, 3: 159-164.PubMed
- Webb WB, Ross W: Estimation of the passing of four consecutive hours. Percept Mot Skills. 1972, 35: 768-770. 10.2466/pms.19126.96.36.1998.PubMedView Article
- Moorcroft WH, Kayser KH, Griggs AJ: Subjective and objective confirmation of the ability to self-awaken at a self-predetermined time without using external means. Sleep. 1997, 20: 40-45.PubMed
- Kaida K, Nakano E, Nittono H, Hayashi M, Hori T: The effects of self-awakening on heart rate activity in a short afternoon nap. Clin Neurophysiol. 2003, 114: 1896-1901. 10.1016/S1388-2457(03)00167-6.PubMedView Article
- Ikeda H, Hayashi M: The effect of self-awakening from nocturnal sleep on sleep inertia. Biol Psychol. 2010, 83: 15-19. 10.1016/j.biopsycho.2009.09.008.PubMedView Article
- Born J, Hansen K, Marshall L, Molle M, Fehm HL: Timing the end of nocturnal sleep. Nature. 1999, 397: 29-30. 10.1038/16166.PubMedView Article
- Tang NK, Harvey AG: Time estimation ability and distorted perception of sleep in insomnia. Behav Sleep Med. 2005, 3: 134-150. 10.1207/s15402010bsm0303_2.PubMedView Article
- Bell C: Awakening from sleep at a pre-set time. Percept Mot Skills. 1980, 50: 503-508. 10.2466/pms.19188.8.131.523.View Article
- Aritake-Okada S, Uchiyama M, Suzuki H, Tagaya H, Kuriyama K, Matsuura M, Takahashi K, Higuchi S, Mishima K: Time estimation during sleep relates to the amount of slow wave sleep in humans. Neurosci Res. 2009, 63: 115-121. 10.1016/j.neures.2008.11.001.PubMedView Article
- Zepelin H: REM sleep and the timing of self-awakenings. Bull Psychomonic Soc. 1986, 24: 254-256.View Article
- Kleitman N: Sleep and Wakefullness. 1963, The University of Chicago Press, Chicago & London, 122-126.
- Tart CT: Waking from sleep at a preselected time. J Am Soc Psychosom Dent Med. 1970, 17: 3-16.PubMed
- Lavie P, Oksenberg A, Zomer J: It's time, you must wake up now. Percept Mot Skills. 1979, 49: 447-450. 10.2466/pms.19184.108.40.2067.PubMedView Article
- Aritake S, Uchiyama M, Tagaya H, Suzuki H, Kuriyama K, Ozaki A, Tan X, Shibui K, Kamei Y, Okubo Y, Takahashi K: Time estimation during nocturnal sleep in human subjects. Neurosci Res. 2004, 49: 387-393. 10.1016/j.neures.2004.04.006.PubMedView Article
- Spati J, Munch M, Blatter K, Knoblauch V, Jones LA, Cajochen C: Impact of age, sleep pressure and circadian phase on time-of-day estimates. Behav Brain Res. 2009, 201: 48-52. 10.1016/j.bbr.2009.01.029.PubMedView Article
- Aritake-Okada S, Higuchi S, Suzuki H, Kuriyama K, Enomoto M, Soshi T, Kitamura S, Watanabe M, Hida A, Matsuura M, Uchiyama M, Mishima K: Diurnal fluctuations in subjective sleep time in humans. Neurosci Res. 2010, 68: 225-231. 10.1016/j.neures.2010.07.2040.PubMedView Article
- Hawkins J: Sleep disturbance in intentional self-awakenings: behavior-genetic and transient factors. Percept Mot Skills. 1989, 69: 507-510. 10.2466/pms.19220.127.116.117.PubMedView Article
- Morell V: Setting a biological stopwatch. Science. 1996, 271: 905-906. 10.1126/science.271.5251.905.PubMedView Article
- Schubotz RI, Friederici AD, von Cramon DY: Time perception and motor timing: a common cortical and subcortical basis revealed by fMRI. Neuroimage. 2000, 11: 1-12. 10.1006/nimg.1999.0514.PubMedView Article
- Rao SM, Mayer AR, Harrington DL: The evolution of brain activation during temporal processing. Nat Neurosci. 2001, 4: 317-323. 10.1038/85191.PubMedView Article
- Harrington DL, Boyd LA, Mayer AR, Sheltraw DM, Lee RR, Huang M, Rao SM: Neural representation of interval encoding and decision making. Brain Res Cogn Brain Res. 2004, 21: 193-205. 10.1016/j.cogbrainres.2004.01.010.PubMedView Article
- Jueptner M, Rijntjes M, Weiller C, Faiss JH, Timmann D, Mueller SP, Diener HC: Localization of a cerebellar timing process using PET. Neurology. 1995, 45: 1540-1545. 10.1212/WNL.45.8.1540.PubMedView Article
- Spencer RM, Zelaznik HN, Diedrichsen J, Ivry RB: Disrupted timing of discontinuous but not continuous movements by cerebellar lesions. Science. 2003, 300: 1437-1439. 10.1126/science.1083661.PubMedView Article
- Ivry RB, Spencer RM: The neural representation of time. Curr Opin Neurobiol. 2004, 14: 225-232. 10.1016/j.conb.2004.03.013.PubMedView Article
- Lalonde R, Hannequin D: The neurobiological basis of time estimation and temporal order. Rev Neurosci. 1999, 10: 151-173.PubMed
- Meck WH: Frontal cortex lesions eliminate the clock speed effect of dopaminergic drugs on interval timing. Brain Res. 2006, 1108: 157-167. 10.1016/j.brainres.2006.06.046.PubMedView Article
- Meck WH, Penney TB, Pouthas V: Cortico-striatal representation of time in animals and humans. Curr Opin Neurobiol. 2008, 18: 145-152. 10.1016/j.conb.2008.08.002.PubMedView Article
- Harrington DL, Haaland KY, Knight RT: Cortical networks underlying mechanisms of time perception. J Neurosci. 1998, 18: 1085-1095.PubMed
- Mangels JA, Ivry RB, Shimizu N: Dissociable contributions of the prefrontal and neocerebellar cortex to time perception. Brain Res Cogn Brain Res. 1998, 7: 15-39. 10.1016/S0926-6410(98)00005-6.PubMedView Article
- Maquet P, Lejeune H, Pouthas V, Bonnet M, Casini L, Macar F, Timsit-Berthier M, Vidal F, Ferrara A, Degueldre C, Quaglia L, Delfiore G, Luxen A, Woods R, Mazziotta JC, Comar D: Brain activation induced by estimation of duration: a PET study. Neuroimage. 1996, 3: 119-126. 10.1006/nimg.1996.0014.PubMedView Article
- Shiotsuka S, Atsumi Y, Ogata S, Yamamoto R, Igawa M, Takahashi K, Hirasawa H, Koyama K, Maki A, Yamashita Y, Koizumi H, Toru M: Cerebral blood volume in the sleep measured by near-infrared spectroscopy. Psychiatry Clin Neurosci. 1998, 52: 172-173. 10.1111/j.1440-1819.1998.tb01012.x.PubMedView Article
- Hoshi Y, Onoe H, Watanabe Y, Andersson J, Bergstrom M, Lilja A, Langstrom B, Tamura M: Non-synchronous behavior of neuronal activity, oxidative metabolism and blood supply during mental tasks in man. Neurosci Lett. 1994, 172: 129-133. 10.1016/0304-3940(94)90679-3.PubMedView Article
- Spielman AJ, Zhang G, Yang CM, D'Ambrosio P, Serizawa S, Nagata M, von Gizycki H, Alfano RR: Intracerebral hemodynamics probed by near infrared spectroscopy in the transition between wakefulness and sleep. Brain Res. 2000, 866: 313-325. 10.1016/S0006-8993(00)02320-9.PubMedView Article
- Fantini S, Aggarwal P, Chen K, Franceschini MA, Ehrenberg BL: Near-infrared spectroscopy and polysomnography during all-night sleep in human subjects. Proc SPIE. 2003, 5068: 155-162.View Article
- Pierro ML, Sassaroli A, Bergethon PR, Ehrenberg BL, Fantini S: Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: a sleep study in human subjects. Neuroimage. 2012, 63: 1571-1584. 10.1016/j.neuroimage.2012.07.015.PubMed CentralPubMedView Article
- Hoshi Y, Mizukami S, Tamura M: Dynamic features of hemodynamic and metabolic changes in the human brain during all-night sleep as revealed by near-infrared spectroscopy. Brain Res. 1994, 652: 257-262. 10.1016/0006-8993(94)90235-6.PubMedView Article
- Hayakawa T, Terashima M, Kayukawa Y, Ohta T, Okada T: Changes in cerebral oxygenation and hemodynamics during obstructive sleep apneas. Chest. 1996, 109: 916-921. 10.1378/chest.109.4.916.PubMedView Article
- Kusaka T, Kawada K, Okubo K, Nagano K, Namba M, Okada H, Imai T, Isobe K, Itoh S: Noninvasive optical imaging in the visual cortex in young infants. Hum Brain Mapp. 2004, 22: 122-132. 10.1002/hbm.20020.PubMedView Article
- Shinba T, Nagano M, Kariya N, Ogawa K, Shinozaki T, Shimosato S, Hoshi Y: Near-infrared spectroscopy analysis of frontal lobe dysfunction in schizophrenia. Biol Psychiatry. 2004, 55: 154-164. 10.1016/S0006-3223(03)00547-X.PubMedView Article
- Schroeter ML, Kupka T, Mildner T, Uludag K, von Cramon DY: Investigating the post-stimulus undershoot of the BOLD signal–a simultaneous fMRI and fNIRS study. Neuroimage. 2006, 30: 349-358. 10.1016/j.neuroimage.2005.09.048.PubMedView Article
- Koch SP, Werner P, Steinbrink J, Fries P, Obrig H: Stimulus-induced and state-dependent sustained gamma activity is tightly coupled to the hemodynamic response in humans. J Neurosci. 2009, 29: 13962-13970. 10.1523/JNEUROSCI.1402-09.2009.PubMedView Article
- Cui X, Bray S, Bryant DM, Glover GH, Reiss AL: A quantitative comparison of NIRS and fMRI across multiple cognitive tasks. Neuroimage. 2011, 54: 2808-2821. 10.1016/j.neuroimage.2010.10.069.PubMed CentralPubMedView Article
- Strangman G, Culver JP, Thompson JH, Boas DA: A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation. Neuroimage. 2002, 17: 719-731. 10.1006/nimg.2002.1227.PubMedView Article
- Tamura T, Eda H, Takada M, Kubodera T: New instrument for monitoring hemoglobin oxygenation. Adv Exp Med Biol. 1989, 248: 103-107. 10.1007/978-1-4684-5643-1_13.PubMedView Article
- Soshi T, Kuriyama K, Aritake S, Enomoto M, Hida A, Tamura M, Kim Y, Mishima K: Sleep deprivation influences diurnal variation of human time perception with prefrontal activity change: a functional near-infrared spectroscopy study. PLoS One. 2010, 5: e8395-10.1371/journal.pone.0008395.PubMed CentralPubMedView Article
- Wray S, Cope M, Delpy DT, Wyatt JS, Reynolds EOR: Characterization of the near-infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation. Biochim Biophys Acta. 1988, 933: 184-192. 10.1016/0005-2728(88)90069-2.PubMedView Article
- Matcher SL, Elwell CE, Cooper CE, Cope M, Deipy DT: Performance comparison of several published tissue near-infrared spectroscopy algorithms. Anal Biochem. 1995, 227: 54-68. 10.1006/abio.1995.1252.PubMedView Article
- Laser Institute of America: American National Standards for the Safe Use of Lasers. 2007, American National Standards Institute, Orland
- Rechtschaffen A, Kales A: A manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. 1968, Brain Information Service/Brain Research Institute, University of California, Los Angeles
- American Sleep Disorders Association: EEG arousals: scoring rules and examples: a preliminary report from the sleep disorders atlas task force of the American sleep disorders association. Sleep. 1992, 15: 173-184.
- Hoshi Y, Kobayashi N, Tamura M: Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model. J Appl Physiol. 2001, 90: 1657-1662.PubMed
- Hall W: The time sense. Br J Psychiatry. 1927, 73: 421-428. 10.1192/bjp.73.302.421.View Article
- Brush EN: Observations on temporal judgement during sleep. Am J Psycho. 1930, 42: 408-441. 10.2307/1415435.View Article
- Hono T, Hiroshige Y, Miyata Y: Nocturnal sleep at a predetermined time in health undergraduate student. Kawasaki Med J. 1991, 1: 209-215.
- Kubota Y, Takasu NN, Horita S, Kondo M, Shimizu M, Okada T, Wakamura T, Toichi M: Dorsolateral prefrontal cortical oxygenation during REM sleep in humans. Brain Res. 2011, 1389: 83-92.PubMedView Article
- Coull JT, Vidal F, Nazarian B, Macar F: Functional anatomy of the attentional modulation of time estimation. Science. 2004, 303: 1506-1508. 10.1126/science.1091573.PubMedView Article
- Bonne O, Gilboa A, Louzoun Y, Brandes D, Yona I, Lester H, Barkai G, Freedman N, Chisin R, Shalev AY: Resting regional cerebral perfusion in recent posttraumatic stress disorder. Biol Psychiatry. 2003, 54: 1077-1086. 10.1016/S0006-3223(03)00525-0.PubMedView Article
- Ottowitz WE, Dougherty DD, Sirota A, Niaura R, Rauch SL, Brown WA: Neural and endocrine correlates of sadness in women: implications for neural network regulation of HPA activity. J Neuropsychiatry Clin Neurosci. 2004, 16: 446-455. 10.1176/appi.neuropsych.16.4.446.PubMedView Article
- Wang J, Rao H, Wetmore GS, Furlan PM, Korczykowski M, Dinges DF, Detre JA: Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress. Proc Natl Acad Sci USA. 2005, 102: 17804-17809. 10.1073/pnas.0503082102.PubMed CentralPubMedView Article
- Urry HL, van Reekum CM, Johnstone T, Kalin NH, Thurow ME, Schaefer HS, Jackson CA, Frye CJ, Greischar LL, Alexander AL, Davidson RJ: Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. J Neurosci. 2006, 26: 4415-4425. 10.1523/JNEUROSCI.3215-05.2006.PubMedView Article
- Edinger JD, Krystal AD: Subtyping primary insomnia: is sleep state misperception a distinct clinical entity?. Sleep Med Rev. 2003, 7: 203-214. 10.1053/smrv.2002.0253.PubMedView Article
- American Academy of Sleep Medicine: ICSD-2- International Classification of Sleep Disorders, 2nd ed.: Diagnostic and Coding Manual. 2005, American Academy of Sleep Medicine, Rochester
- Fernandez-Mendoza J, Calhoun SL, Bixler EO, Karataraki M, Liao D, Vela-Bueno A, Jose Ramos-Platon M, Sauder KA, Basta M, Vgontzas AN: Sleep misperception and chronic insomnia in the general population: role of objective sleep duration and psychological profiles. Psychosom Med. 2011, 73: 88-97. 10.1097/PSY.0b013e3181fe365a.PubMed CentralPubMedView Article
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