Volume 12 Supplement 1

Twentieth Annual Computational Neuroscience Meeting: CNS*2011

Open Access

Modulation of thalamocortical relay by basal ganglia in Parkinson’s disease and dystonia

  • Yixin Guo1,
  • Choongseok Park2,
  • Min Rong1,
  • Robert M Worth3 and
  • Leonid L Rubchinsky2, 4Email author
BMC Neuroscience201112(Suppl 1):P275

DOI: 10.1186/1471-2202-12-S1-P275

Published: 18 July 2011

Two major neurological disorders – Parkinson’s disease and dystonia – are believed to involve pathology in the activity of the basal ganglia, a subcortical brain structure, whose output nuclei (internal Globus Pallidus, GPi) projects to thalamus and modulates thalamocortical relay. While these disorders may ultimately involve different network and cellular pathologies, some pathological physiology may be shared between them because surgical treatment of both conditions includes surgical lesion or electrical stimulation to GPi (pallidotomy and GPi DBS). This work compares the thalamocortical relay responses to inhibitory inputs from internal segment of GPi in Parkinson’s disease and in dystonia.

Experimental data suggest that both conditions are marked by stronger oscillatory activity. In dystonia this activity becomes pathologically strong in the theta and alpha bands [1, 2], while in Parkinson’s disease this is the beta-band activity [3]. The activity itself is patterned in time [4], complicating the computational study of its role. To compare the modulation of thalamocortical relay, we use experimental data recorded from GPi of human subjects with Parkinson’s disease or dystonia and study the difference of the quality of thalamocortical relay in these conditions following the computational setup, presented earlier in [5].

The results of the study of the “hybrid” system (computational model of TC cell modulated by experimental data) reveal a substantial similarity in the properties of relay in Parkinson’s disease and in dystonia. TC relay fidelity is substantially impaired due to the pathological pattern of GPi signals in both conditions. The results are robust with respect to variations of the model details and the types of incoming excitatory synaptic input.

The results suggest that even though the rhythmicity in Parkinson’s disease and dystonia are confined to different frequency bands, their effect on the dynamics of downstream circuits is similar. Thus given the differences in dystonic and parkinsonian symptoms these results suggest the existence of mechanisms beyond pathological rhythmicity and thalamocortical relay in at least in one of the conditions. On the other hand, overlap in some motor deficits of dystonia and Parkinson’s disease may be attributed to the existence of similar pathological rhythmicities and the resulting deficiencies of thalamic relay.



This study was supported by NIH grant R01NS067200 (NSF/NIH CRCNS program) and Antelo Devereux Award from Drexel University.

Authors’ Affiliations

Department of Mathematics, Drexel University
Department of Mathematical Sciences and Center for Mathematical Biosciences, Indiana University Purdue University Indianapolis
Department of Neurological Surgery, Indiana University School of Medicine
Stark Neurosciences Research Institute, Indiana University School of Medicine


  1. Hammond C, Bergman H, Brown P: Pathological synchronization in Parkinson's disease: networks, models and treatments. Trends Neurosci. 2007, 30: 357-364. 10.1016/j.tins.2007.05.004.View ArticlePubMedGoogle Scholar
  2. Silberstein P, Kühn AA, Kupsch A, Trottenberg T, Krauss JK, Wöhrle JC, Mazzone P, Insola A, Di Lazzaro V, Oliviero A, Aziz T, Brown P: Patterning of globus pallidus local field potentials differs between Parkinson's disease and dystonia. Brain. 2003, 126: 2597-2608. 10.1093/brain/awg267.View ArticlePubMedGoogle Scholar
  3. Starr PA, Rau GM, Davis V, Marks WJ, Ostrem JL, Simmons D, Lindsey N, Turner RS: Spontaneous pallidal neuronal activity in human dystonia: comparison with Parkinson's disease and normal macaque. J Neurophysiol. 2005, 93: 3165-3176. 10.1152/jn.00971.2004.View ArticlePubMedGoogle Scholar
  4. Park C, Worth RM, Rubchinsky LL: Fine temporal structure of beta oscillations synchronization in subthalamic nucleus in Parkinson's disease. J Neurophysiol. 2010, 103: 2707-2716. 10.1152/jn.00724.2009.PubMed CentralView ArticlePubMedGoogle Scholar
  5. Guo Y, Rubin JE, McIntyre CC, Vitek JL, Terman D: Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model. J Neurophysiol. 2008, 99: 1477-1492. 10.1152/jn.01080.2007.View ArticlePubMedGoogle Scholar


© Guo et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.