Volume 12 Supplement 1
Mathematical model for metabolic neuro-hemodynamic coupling
© Kang et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Via advances of measuring techniques, neuronal activities have been estimated in more detail. Especially, by using the fMRI method, the BOLD (Blood Oxygen Level Dependent) Signal, which is defined by the hemoglobin concentration in the blood vessel, shows various activities of neurons near the vessel. Such BOLD signals are described by the hemoglobin level, vessel volume, and blood vessel flow, which are determined via the Balloon model . Otherwise, the oxygen and the glucose, which have the important role for the neuronal activity, are transported from the blood vessel to the neuron directly or indirectly through the astrocyte. So, in order to explain the contribution of neuronal activity to the alteration of BOLD signal, it has been needed to consider the metabolic pathway which describes the oxygen and glucose consumption process of the neuron and the astrocyte . Here, for describing the relationship between the blood oxygen level and the neuronal activity, we introduce the mathematical model for the interactions among a neuron, astrocyte, and capillary. Especially, we adapt the two compartment neuron model, which constitutes somatic and dendritic parts, for observing the alteration of the BOLD signal depending on the various neuronal spike types , and investigate the sodium, ATP, lactate, glucose, oxygen concentrations in the neuron and astrocyte
This work was supported by NAP of the Korean Research Council of Fundamental Science & Technology.
- Friston KJ, Mechelli A, Turner R, Price CJ: Nonlinear responses in fMRI: the Balloon model, Volterra kernels, and other hemodynamics. Neuroimage. 2000, 12 (4): 466-477. 10.1006/nimg.2000.0630.View ArticlePubMedGoogle Scholar
- Aubert A, Costalat R: A model of the coupling between brain electrical activity, metabolism, and hemodynamics: application to the interpretation of functional neuroimaging. Neuroimage. 2002, 17 (3): 1162-1181. 10.1006/nimg.2002.1224.View ArticlePubMedGoogle Scholar
- Wang XJ: Fast burst firing and short-term synaptic plasticity: a model of neocortical chattering neurons. Neuroscience. 1999, 89 (2): 347-362. 10.1016/S0306-4522(98)00315-7.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.