Volume 11 Supplement 1
Phase response analysis during in vivo-like high conductance states; dendritic SK determines the mean and variance of responses to dendritic excitation
© Schultheiss et al; licensee BioMed Central Ltd. 2010
Published: 20 July 2010
A neuron’s phase response curve (PRC) describes how synaptic inputs at different times during the spike cycle affect the timing of subsequent spikes, and PRC analysis is a powerful technique for predicting and interpreting the emergence of synchronous modes in synaptically coupled networks and neuronal populations receiving common input. However, neuronal PRCs are typically measured during intrinsic pacemaking which may not reflect neuronal excitability and dynamics during high conductance states generated by complex network activity in vivo. Using a full morphological model of a globus pallidus (GP) neuron we have recently demonstrated that during intrinsic pacemaking, somatic PRCs for GP neurons are type I, i.e. excitatory inputs at all phases of the spike cycle advance the spontaneous spiking rhythm1. We also demonstrated that synaptic excitation of the distal dendrite can paradoxically delay subsequent spiking when delivered at some phases of the spike cycle (yielding a type II PRC) as a consequence of dendritic activation of the small conductance calcium-activated potassium current, SK1. Since during high conductance states spike timing is determined by a balance between intrinsic mechanisms and synaptic input fluctuations, in this study we investigated how somatic and dendritic phase response properties of the GP model are affected by ongoing stochastic synaptic background activity.
- Schultheiss NW, Edgerton JR, Jaeger D: Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. J Neurosci. 2010, 30: 2767-2782. 10.1523/JNEUROSCI.3959-09.2010.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd.