Volume 10 Supplement 1

Eighteenth Annual Computational Neuroscience Meeting: CNS*2009

Open Access

Exploration of the lamprey pallidal neurons – a combined computational and experimental study

  • Ebba M Samuelsson1Email author,
  • Russell H Hill1 and
  • Jeanette Hellgren Kotaleski1, 2
BMC Neuroscience200910(Suppl 1):P32

DOI: 10.1186/1471-2202-10-S1-P32

Published: 13 July 2009

Background

The cortex-basal ganglia-thalamic loops are critical for the selection and initiation of motor actions [1]. The output stage of the basal ganglia, Globus Pallidus interna (GPi) and Substantia Nigra reticulata (SNr) in primates, plays an important role by providing tonic inhibition to motor centers in the brain stem and thalamus. GPi/SNr are controlled by input from the striatum, the input stage of the basal ganglia and also by other basal ganglia nuclei, Globus Pallidus externa (GPe) and Subthalamic nucleus (STN). In the present combined experimental and computational study, we investigate the membrane properties and the synaptic control of the neurons in the lamprey basal ganglia output stages. We have combined electrophysiological and immunohistochemical studies to investigate morphology and physiology properties. Using patch clamp techniques, we have recorded spontaneous activity and membrane properties [unpublished data].

Model

We have constructed a model representing lamprey pallidal neuron [2] based on a previously published GPe/STN model neuron [3]. The model was re-implemented in GENESIS and tuned to replicate passive membrane properties of a lamprey pallidal neuron. Dendrites were added based on projection seen in the lamprey. The membrane conductances have been modified to fit the experimental results obtained from the lamprey preparation.

Computational investigation

The GABA synapses are differentially located on the soma-dendritic tree, while the input from STN is more widespread [4]. We have explored the impact of this spatially distributed synaptic input originating from the different nuclei in the basal ganglia and discuss this in relation of what is known of how the input might be activated during physiological situations [5]. Furthermore, we have studied the role of synaptic input for spontaneous activity.

Authors’ Affiliations

(1)
Department of Neuroscience, Karolinska Institute
(2)
School of Computer Science and Communication, Royal Institute of Technology, AlbaNova University Centre

References

  1. Grillner S, Hellgren J, Ménard A, Saitoh K, Wikström MA: Mechanisms for selection of basic motor programs-roles for the striatum and pallidum. Trends Neurosci. 2005, 28: 364-70. Review.PubMedView ArticleGoogle Scholar
  2. Robertson B, Saitoh K, Ménard A, Grillner S: Afferents of the lamprey optic tectum With special reference to the GABA input: Combined tracing and immunohistochemical study. J Comparative Neurology. 2006, 499: 106-119.View ArticleGoogle Scholar
  3. Terman D, Rubin JE, Yew AC, Wilson CJ: Activity patterns in a model for the subthalamopallidal network of the basal ganglia. J Neurosci. 2002, 22: 2963-2976.PubMedGoogle Scholar
  4. Nambu A: Globus pallidus internal segment. Progress in Brain Research. 2007, 160: 135-150.PubMedView ArticleGoogle Scholar
  5. Tachibana Y, Kita H, Chiken S, Takada M, Nambu A: Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys. Eur J Neurosci. 2008, 27: 238-253.PubMedView ArticleGoogle Scholar

Copyright

© Samuelsson et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

Advertisement