Volume 10 Supplement 1
Influence of external input on waxing and waning of neuronal network oscillations
© Gonzalez et al; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
Experimental observations have reported modulation of cortical oscillations as phases of high synchronization (waxing) followed by periods of reduced synchronization (waning) [1–3]. Although the phenomenon is present in almost all frequency bands, it is still not understood how this is driven. Here we study whether this phenomenon can occur in a network of inhibitory (I) and excitatory (E) cells and what effect external inputs have.
Using NEURON, we model a network of N e excitatory and N i inhibitory cells such that N e /N i = 4. The cells have a single compartment, and include passive channels and voltage dependent Na+, K+ channels. Synaptic connections are random, projecting GABA synapses from I to I and I to E cells and AMPA synapses from E to E and E to I cells. To stimulate the network, each cell receives a baseline of current and a stream of spikes delivered at random intervals across the simulated period.
The work was supported by the EU grant MC-RTN NEURoVERS-it (019247).
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