Volume 10 Supplement 1
The spatial information content of DG inputs
© Cerasti and Treves; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
In the mammalian hippocampus, the dentate gyrus (DG) is characterized by sparse and powerful projections to CA3 cells, the so-called mossy fibers. These projections appear to duplicate, in terms of the information they convey, what CA3 cells already receive from entorhinal cortex layer II cells (ECII). It has been hypothesized that the function of the mossy fibers is to enforce a new pattern of activity onto CA3 cells, which has to represent a new memory, prevailing over the interference produced by the traces of older memories already stored on CA3.
Such an hypothesis is supported by a mathematical model which compares the amount of information carried by both inputs to CA3  and it seems to be supported also by experimental studies with rodents. A recent experimental study has clarified the nature of the spatial representations in the DG . This allows us to study the information flow from DG to CA3 in a more detailed and quantitative way and, moreover, to apply that to 2-D spatial representations.
Methods and results
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This article is published under license to BioMed Central Ltd.