Figure 4
From: Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
Fos-IR FTO neurons in the PVN and ARC at initiation and termination of feeding. c-Fos was detected by IHC, whereas FTO mRNA by ISH. A. Percentage of Fos-positive FTO cells in the PVN and ARC. B and C. Coronal sections of mice perfused at the beginning and at the end of a meal. Thin arrows, Fos-positive nuclei, thick solid arrows, Fos-positive FTO cells, open arrows, FTO neurons devoid of Fos. Scale bar: 0.02 mm. D. Schematic representation of distribution of Fos-positive FTO cells (each blue point indicates one such cell) in the representative sections encompassing the PVN and ARC. dc, dorsal cap; lm, lateral magnocellular; mm, medial magnocellular; mp, medial parvocellular.