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  1. Research article

    Expertise-related functional brain network efficiency in healthy older adults

    In view of age-related brain changes, identifying factors that are associated with healthy aging are of great interest. In the present study, we compared the functional brain network characteristics of three g...

    Julia C. Binder, Ladina Bezzola, Aurea I. S. Haueter, Carina Klein, Jürg Kühnis, Hansruedi Baetschmann and Lutz Jäncke

    BMC Neuroscience 2017 18:2

    Published on: 3 January 2017

  2. Research Article

    Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging

    Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0–24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)—cons...

    Friedrich Wetterling, Eva Chatzikonstantinou, Laurent Tritschler, Stephen Meairs, Marc Fatar, Lothar R. Schad and Saema Ansar

    BMC Neuroscience 2016 17:82

    Published on: 7 December 2016

  3. Research Article

    Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice

    It is known that tooth loss is known to be a risk factor for Alzheimer’s disease and soft diet feeding induces memory impairment. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is asso...

    Yosuke Takeda, Hiroshi Oue, Shinsuke Okada, Akira Kawano, Katsunori Koretake, Makoto Michikawa, Yasumasa Akagawa and Kazuhiro Tsuga

    BMC Neuroscience 2016 17:81

    Published on: 5 December 2016

  4. Research Article

    Bone morphogenetic protein-2-mediated pain and inflammation in a rat model of posterolateral arthrodesis

    Bone morphogenetic protein-2 (BMP-2) is a pleiotropic, secreted molecule with diverse effects. The potent ability of BMP-2 to stimulate bone growth prompted its widespread clinical use for arthrodesis (spine f...

    Kendall Mitchell, Jill P. Shah, Clifton L. Dalgard, Lyubov V. Tsytsikova, Ashley C. Tipton, Anton E. Dmitriev and Aviva J. Symes

    BMC Neuroscience 2016 17:80

    Published on: 1 December 2016

  5. Research Article

    Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder

    Obsessive–compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenet...

    Carolina Cappi, Juliana Belo Diniz, Guaraci L. Requena, Tiaya Lourenço, Bianca Cristina Garcia Lisboa, Marcelo Camargo Batistuzzo, Andrea H. Marques, Marcelo Q. Hoexter, Carlos A. Pereira, Euripedes Constantino Miguel and Helena Brentani

    BMC Neuroscience 2016 17:79

    Published on: 30 November 2016

  6. Research Article

    CatWalk gait analysis in a rat model of multiple sclerosis

    Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis. The characteristic feature of the MOG-EAE model in Brown...

    Sabine Herold, Prateek Kumar, Klaus Jung, Irina Graf, Henrike Menkhoff, Xenia Schulz, Mathias Bähr and Katharina Hein

    BMC Neuroscience 2016 17:78

    Published on: 30 November 2016

  7. Research Article

    Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

    α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic ...

    Tatsunori Maekawa, Toshikuni Sasaoka, Sadahiro Azuma, Takafumi Ichikawa, Heather L. Melrose, Matthew J. Farrer and Fumiya Obata

    BMC Neuroscience 2016 17:77

    Published on: 30 November 2016

  8. Research article

    Genotypic differences in intruder-evoked immediate early gene activation in male, but not female, vasopressin 1b receptor knockout mice

    The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mi...

    Shannah K. Witchey, Erica L. Stevenson and Heather K. Caldwell

    BMC Neuroscience 2016 17:75

    Published on: 24 November 2016

  9. Research article

    Interleukin-1 receptor (IL-1R) mediates epilepsy-induced sleep disruption

    Sleep disruptions are common in epilepsy patients. Our previous study demonstrates that homeostatic factors and circadian rhythm may mediate epilepsy-induced sleep disturbances when epilepsy occurs at differen...

    Tzu-Rung Huang, Shuo-Bin Jou, Yu-Ju Chou, Pei-Lu Yi, Chun-Jen Chen and Fang-Chia Chang

    BMC Neuroscience 2016 17:74

    Published on: 22 November 2016

  10. Review

    mTOR and MAPK: from localized translation control to epilepsy

    Epilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse and not really understood. All in common is the mi...

    Helena F. Pernice, Rico Schieweck, Michael A. Kiebler and Bastian Popper

    BMC Neuroscience 2016 17:73

    Published on: 17 November 2016

  11. Research article

    TfAP-2 is required for night sleep in Drosophila

    The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been lin...

    Mariya M. Kucherenko, Vinodh Ilangovan, Bettina Herzig, Halyna R. Shcherbata and Henrik Bringmann

    BMC Neuroscience 2016 17:72

    Published on: 9 November 2016

  12. Methodology article

    A method for isolation of cone photoreceptors from adult zebrafish retinae

    Cone photoreceptors are specialised sensory retinal neurons responsible for photopic vision, colour perception and visual acuity. Retinal degenerative diseases are a heterogeneous group of eye diseases in whic...

    Antonino Glaviano, Andrew J. Smith, Alfonso Blanco, Sarah McLoughlin, Maria L. Cederlund, Theresa Heffernan, Beata Sapetto-Rebow, Yolanda Alvarez, Jun Yin and Breandán N. Kennedy

    BMC Neuroscience 2016 17:71

    Published on: 7 November 2016

  13. Research article

    Severe respiratory changes at end stage in a FUS-induced disease state in adult rats

    Fused in sarcoma (FUS) is an RNA-binding protein associated with the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. ALS manifests in patients as a progres...

    Kasey L. Jackson, Hemangini A. Dhaibar, Robert D. Dayton, Sergio G. Cananzi, William G. Mayhan, Edward Glasscock and Ronald L. Klein

    BMC Neuroscience 2016 17:69

    Published on: 28 October 2016

  14. Research article

    ‘Proactive’ use of cue-context congruence for building reinforcement learning’s reward function

    Reinforcement learning is a fundamental form of learning that may be formalized using the Bellman equation. Accordingly an agent determines the state value as the sum of immediate reward and of the discounted ...

    Judit Zsuga, Klara Biro, Gabor Tajti, Magdolna Emma Szilasi, Csaba Papp, Bela Juhasz and Rudolf Gesztelyi

    BMC Neuroscience 2016 17:70

    Published on: 28 October 2016

  15. Research article

    Results on the spatial resolution of repetitive transcranial magnetic stimulation for cortical language mapping during object naming in healthy subjects

    The spatial resolution of repetitive navigated transcranial magnetic stimulation (rTMS) for language mapping is largely unknown. Thus, to determine a minimum spatial resolution of rTMS for language mapping, we...

    Nico Sollmann, Theresa Hauck, Lorena Tussis, Sebastian Ille, Stefanie Maurer, Tobias Boeckh-Behrens, Florian Ringel, Bernhard Meyer and Sandro M. Krieg

    BMC Neuroscience 2016 17:67

    Published on: 24 October 2016

  16. Research article

    Neuroprotective effects of HTR1A antagonist WAY-100635 on scopolamine-induced delirium in rats and underlying molecular mechanisms

    Limited surveys have assessed the performance of 5-hydroxytreptamine receptor 1A and its antagonist WAY-100635 in pharmacological manipulations targeting delirium therapies. The purpose of this paper was to as...

    Yimin Qiu, Dongmei Chen, Xiaojing Huang, Lina Huang, Liang Tang, Jihong Jiang, Lianhua Chen and Shitong Li

    BMC Neuroscience 2016 17:66

    Published on: 19 October 2016

  17. Research article

    Cortical processes of speech illusions in the general population

    There is evidence that experimentally elicited auditory illusions in the general population index risk for psychotic symptoms. As little is known about underlying cortical mechanisms of auditory illusions, an ...

    E. Schepers, L. Bodar, J. van Os and R. Lousberg

    BMC Neuroscience 2016 17:65

    Published on: 18 October 2016

  18. Research article

    Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes

    Cerebral oedema is closely related to the permeability of blood–brain barrier, vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 2 (VEGFR2) all of which are...

    Linqiang Huang, Wei Cao, Yiyu Deng, Gaofeng Zhu, Yongli Han and Hongke Zeng

    BMC Neuroscience 2016 17:64

    Published on: 13 October 2016

  19. Research article

    Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy

    Bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively there are few publications on the effects of short-term a...

    Naserddine Hamadi, Azimullah Sheikh, Nather Madjid, Loai Lubbad, Naheed Amir, Safa Al-Deen Saudi Shehab, Fatima Khelifi-Touhami and Abdu Adem

    BMC Neuroscience 2016 17:61

    Published on: 1 September 2016

  20. Research article

    Cerebral blood perfusion changes in amputees with myoelectric hands after rehabilitation: a SPECT computer-aided analysis

    Rehabilitation, which is essential for amputees with myoelectric hands, can improve the quality of daily life by remodeling the neuron network. In our study, we aim to develop a cerebral blood perfusion (CBF) ...

    Qiufang Liu, Xiujuan Zheng, Panli Li, Lian Xu, Longwen He, Zhao Mei, Yinyan Zhu, Gang Huang, Chunlong Zhong and Shaoli Song

    BMC Neuroscience 2016 17:59

    Published on: 31 August 2016

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