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  1. Research article

    Selenium suppresses glutamate-induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells

    Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    BMC Neuroscience 2017 18:15

    Published on: 19 January 2017

  2. Research Article

    Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells

    Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

    Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

    BMC Neuroscience 2017 18:14

    Published on: 17 January 2017

  3. Research article

    Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke

    Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determin...

    Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús and Joan Martí-Fàbregas

    BMC Neuroscience 2017 18:13

    Published on: 13 January 2017

  4. Research article

    Genistein protects against Aβ25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers

    Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significan...

    Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen and Hong Yang

    BMC Neuroscience 2017 18:12

    Published on: 12 January 2017

  5. Research Article

    CX3C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke

    The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also bee...

    Gerlinde van der Maten, Vivien Henck, Tadeusz Wieloch and Karsten Ruscher

    BMC Neuroscience 2017 18:11

    Published on: 6 January 2017

  6. Research article

    Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging

    Previous neuroimaging studies have shown the hemodynamic effect of either preconditioning or postconditioning anesthesia in ischemic stroke model. However, the anesthetic effect in hemodynamics during and imm...

    Hongyang Lu, Yao Li, Bin Bo, Lu Yuan, Xiaodan Lu, Hangdao Li and Shanbao Tong

    BMC Neuroscience 2017 18:10

    Published on: 5 January 2017

  7. Research article

    Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice

    It is well-established that organizational effects of sex steroids during early development are fundamental for sex-typical displays of, for example, mating and aggressive behaviors in rodents and other specie...

    Anna Zettergren, Sara Karlsson, Erik Studer, Anna Sarvimäki, Petronella Kettunen, Annika Thorsell, Carina Sihlbom and Lars Westberg

    BMC Neuroscience 2017 18:9

    Published on: 5 January 2017

  8. Research article

    Immunization with neural derived peptides plus scar removal induces a permissive microenvironment, and improves locomotor recovery after chronic spinal cord injury

    Immunization with neural derived peptides (INDP) as well as scar removal—separately—have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compar...

    Roxana Rodríguez-Barrera, Adrián Flores-Romero, Ana María Fernández-Presas, Elisa García-Vences, Raúl Silva-García, Mina Konigsberg, Liliana Blancas-Espinoza, Vinnitsa Buzoianu-Anguiano, Karla Soria-Zavala, Paola Suárez-Meade and Antonio Ibarra

    BMC Neuroscience 2017 18:7

    Published on: 5 January 2017

  9. Research Article

    The variability of motor evoked potential latencies in neurosurgical motor mapping by preoperative navigated transcranial magnetic stimulation

    Recording of motor evoked potentials (MEPs) is used during navigated transcranial magnetic stimulation (nTMS) motor mapping to locate motor function in the human brain. However, factors potentially underlying ...

    Nico Sollmann, Lucia Bulubas, Noriko Tanigawa, Claus Zimmer, Bernhard Meyer and Sandro M. Krieg

    BMC Neuroscience 2017 18:5

    Published on: 3 January 2017

  10. Research article

    Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headache

    Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are uncl...

    Aree Wanasuntronwong, Ukkrit Jansri and Anan Srikiatkhachorn

    BMC Neuroscience 2017 18:1

    Published on: 3 January 2017

  11. Research article

    Expertise-related functional brain network efficiency in healthy older adults

    In view of age-related brain changes, identifying factors that are associated with healthy aging are of great interest. In the present study, we compared the functional brain network characteristics of three g...

    Julia C. Binder, Ladina Bezzola, Aurea I. S. Haueter, Carina Klein, Jürg Kühnis, Hansruedi Baetschmann and Lutz Jäncke

    BMC Neuroscience 2017 18:2

    Published on: 3 January 2017

  12. Research Article

    Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging

    Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0–24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)—cons...

    Friedrich Wetterling, Eva Chatzikonstantinou, Laurent Tritschler, Stephen Meairs, Marc Fatar, Lothar R. Schad and Saema Ansar

    BMC Neuroscience 2016 17:82

    Published on: 7 December 2016

  13. Research Article

    Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice

    It is known that tooth loss is known to be a risk factor for Alzheimer’s disease and soft diet feeding induces memory impairment. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is asso...

    Yosuke Takeda, Hiroshi Oue, Shinsuke Okada, Akira Kawano, Katsunori Koretake, Makoto Michikawa, Yasumasa Akagawa and Kazuhiro Tsuga

    BMC Neuroscience 2016 17:81

    Published on: 5 December 2016

  14. Research Article

    Bone morphogenetic protein-2-mediated pain and inflammation in a rat model of posterolateral arthrodesis

    Bone morphogenetic protein-2 (BMP-2) is a pleiotropic, secreted molecule with diverse effects. The potent ability of BMP-2 to stimulate bone growth prompted its widespread clinical use for arthrodesis (spine f...

    Kendall Mitchell, Jill P. Shah, Clifton L. Dalgard, Lyubov V. Tsytsikova, Ashley C. Tipton, Anton E. Dmitriev and Aviva J. Symes

    BMC Neuroscience 2016 17:80

    Published on: 1 December 2016

  15. Research Article

    Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder

    Obsessive–compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenet...

    Carolina Cappi, Juliana Belo Diniz, Guaraci L. Requena, Tiaya Lourenço, Bianca Cristina Garcia Lisboa, Marcelo Camargo Batistuzzo, Andrea H. Marques, Marcelo Q. Hoexter, Carlos A. Pereira, Euripedes Constantino Miguel and Helena Brentani

    BMC Neuroscience 2016 17:79

    Published on: 30 November 2016

  16. Research Article

    CatWalk gait analysis in a rat model of multiple sclerosis

    Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis. The characteristic feature of the MOG-EAE model in Brown...

    Sabine Herold, Prateek Kumar, Klaus Jung, Irina Graf, Henrike Menkhoff, Xenia Schulz, Mathias Bähr and Katharina Hein

    BMC Neuroscience 2016 17:78

    Published on: 30 November 2016

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