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  1. Research article

    Quantitative analysis of axon collaterals of single pyramidal cells of the anterior piriform cortex of the guinea pig

    The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the piriform cortex (APC) has been the focus of cortical-level studies of olfactory codin...

    Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda, Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda

    BMC Neuroscience 2017 18:25

    Published on: 8 February 2017

  2. Research article

    Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice

    Synucleinopathies such as Parkinson’s disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly formed by α-synuclein inclusions, a protein crucia...

    R. Rabl, C. Breitschaedel, S. Flunkert, S. Duller, D. Amschl, J. Neddens, V. Niederkofler, E. Rockenstein, E. Masliah, H. Roemer and B. Hutter-Paier

    BMC Neuroscience 2017 18:22

    Published on: 31 January 2017

  3. Research article

    Evoked potentials and behavioral performance during different states of brain arousal

    Previous studies compared evoked potentials (EPs) between several sleep stages but only one uniform wake state. However, using electroencephalography (EEG), several arousal states can be distinguished before s...

    Jue Huang, Tilman Hensch, Christine Ulke, Christian Sander, Janek Spada, Philippe Jawinski and Ulrich Hegerl

    BMC Neuroscience 2017 18:21

    Published on: 25 January 2017

  4. Research article

    TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

    TDP-43 aggregates accumulate in individuals affected by amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, representing potential diagnostic and therapeutic targets. Using an atomic forc...

    Stephanie M. Williams, Galam Khan, Brent T. Harris, John Ravits and Michael R. Sierks

    BMC Neuroscience 2017 18:20

    Published on: 25 January 2017

  5. Research article

    Selenium suppresses glutamate-induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells

    Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    BMC Neuroscience 2017 18:15

    Published on: 19 January 2017

  6. Research Article

    Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells

    Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

    Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

    BMC Neuroscience 2017 18:14

    Published on: 17 January 2017

  7. Research article

    Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke

    Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determin...

    Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús and Joan Martí-Fàbregas

    BMC Neuroscience 2017 18:13

    Published on: 13 January 2017

  8. Research article

    Genistein protects against Aβ25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers

    Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significan...

    Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen and Hong Yang

    BMC Neuroscience 2017 18:12

    Published on: 12 January 2017

  9. Research Article

    CX3C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke

    The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also bee...

    Gerlinde van der Maten, Vivien Henck, Tadeusz Wieloch and Karsten Ruscher

    BMC Neuroscience 2017 18:11

    Published on: 6 January 2017

  10. Research article

    Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging

    Previous neuroimaging studies have shown the hemodynamic effect of either preconditioning or postconditioning anesthesia in ischemic stroke model. However, the anesthetic effect in hemodynamics during and imm...

    Hongyang Lu, Yao Li, Bin Bo, Lu Yuan, Xiaodan Lu, Hangdao Li and Shanbao Tong

    BMC Neuroscience 2017 18:10

    Published on: 5 January 2017

  11. Research article

    Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice

    It is well-established that organizational effects of sex steroids during early development are fundamental for sex-typical displays of, for example, mating and aggressive behaviors in rodents and other specie...

    Anna Zettergren, Sara Karlsson, Erik Studer, Anna Sarvimäki, Petronella Kettunen, Annika Thorsell, Carina Sihlbom and Lars Westberg

    BMC Neuroscience 2017 18:9

    Published on: 5 January 2017

  12. Research article

    Immunization with neural derived peptides plus scar removal induces a permissive microenvironment, and improves locomotor recovery after chronic spinal cord injury

    Immunization with neural derived peptides (INDP) as well as scar removal—separately—have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compar...

    Roxana Rodríguez-Barrera, Adrián Flores-Romero, Ana María Fernández-Presas, Elisa García-Vences, Raúl Silva-García, Mina Konigsberg, Liliana Blancas-Espinoza, Vinnitsa Buzoianu-Anguiano, Karla Soria-Zavala, Paola Suárez-Meade and Antonio Ibarra

    BMC Neuroscience 2017 18:7

    Published on: 5 January 2017

  13. Research Article

    The variability of motor evoked potential latencies in neurosurgical motor mapping by preoperative navigated transcranial magnetic stimulation

    Recording of motor evoked potentials (MEPs) is used during navigated transcranial magnetic stimulation (nTMS) motor mapping to locate motor function in the human brain. However, factors potentially underlying ...

    Nico Sollmann, Lucia Bulubas, Noriko Tanigawa, Claus Zimmer, Bernhard Meyer and Sandro M. Krieg

    BMC Neuroscience 2017 18:5

    Published on: 3 January 2017

  14. Research article

    Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headache

    Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are uncl...

    Aree Wanasuntronwong, Ukkrit Jansri and Anan Srikiatkhachorn

    BMC Neuroscience 2017 18:1

    Published on: 3 January 2017

  15. Research article

    Expertise-related functional brain network efficiency in healthy older adults

    In view of age-related brain changes, identifying factors that are associated with healthy aging are of great interest. In the present study, we compared the functional brain network characteristics of three g...

    Julia C. Binder, Ladina Bezzola, Aurea I. S. Haueter, Carina Klein, Jürg Kühnis, Hansruedi Baetschmann and Lutz Jäncke

    BMC Neuroscience 2017 18:2

    Published on: 3 January 2017

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