Fig. 2

Auditory brainstem responses post pharmacological treatment in WT Sprague Dawley rats under isoflurane anesthesia. ABR waveforms across different stimulus intensities (90, 70, 50 dB) post intraperitoneal injection with diazepam (3 mg/kg) in magenta; (N = 14), gaboxadol (10 mg/kg) in teal; (N = 14), baclofen (5 mg/kg) in blue; (N = 14), bitopertin (10 mg/kg) in purple, retigabine (3 mg/kg) in red; (N = 18), nicotine (5 mg/kg) in yellow; (N = 14),; (N = 14), or vehicle solution in black (0.9% saline + 0.3% Tween). Within each experimental block, dosing was counterbalanced, and applied 15 min prior to the ABR recordings for all compounds, except for bitopertin (60 min pre-treatment time). The Black bars above the graphs indicate clusters of significant differences between conditions. The Gray bars indicate clusters that have not reached significance threshold post-permutations. Data displayed as mean ± SEM