Fig. 2

TCM architecture and connectivity with six cortical column neural populations and two thalamic populations. Cortical populations include layer 2/3 superficial pyramidal (SP) and superficial interneuron (SI) cells, layer 4 spiny stellate cells (SS), layer 5 deep pyramidal (DP) and deep interneuron (DI) cells, and layer 6 thalamic projection (TP) cells. Thalamic populations include reticular (RT) and relay cells (RL). Connectivity between cells include ascending (in green) and descending (in orange) connections between excitatory cell populations, and inhibitory (in red) and excitatory (in blue) connections between excitatory and inhibitory cell populations. Solid lines indicate connectivity parameters which were allowed to change within the model, and dashed lines indicate fixed parameters. The model also parameterises the decay constants of AMPA, NMDA, GABA-A, GABA-B, M- and H-channels