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Fig. 6 | BMC Neuroscience

Fig. 6

From: Sex differences in response to obesity and caloric restriction on cognition and hippocampal measures of autophagic-lysosomal transcripts and signaling pathways

Fig. 6

Depicts sex-specific changes due to obesity and CR. A illustrates the connections between the ALP signaling and genomic pathways measured in this study. B and C Females were more resistant to metabolic and genomic changes due to obesity than males. In males, expected results were observed via changes in pAKT and mTOR signaling. D and E CR differentially affected females and males; TFE3 was affected in females only and may relate to the genomic changes observed in FNIP2 and Atg12; however, in males Atg7 and Atg12 effects may be via a different transcription factor, like TFEB, which is known to be tied to mTOR signaling

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BMC Neuroscience

ISSN: 1471-2202

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