Table 5 Correlation analysis between the cytokine levels and YGTSS scores of the tic disorder patient subgroups
From: Cytokine levels reflect tic symptoms more prominently during mild phases
Tic subgroup | Cytokine | Motor tic score | Phonic tic score | Total tic score | Impairment score | YGTSS score |
|---|---|---|---|---|---|---|
All patients | GM-CSF | -0.075 | 0.075 | 0.009 | 0.082 | 0.053 |
IFN-α2 | 0.065 | 0.089 | 0.103 | 0.137 | 0.131 | |
IFN-γ | -0.320 | -0.167 | -0.315 | -0.295 | -0.327 | |
IL-1β | 0.014 | 0.092 | 0.075 | 0.108 | 0.100 | |
IL-2 | 0.116 | 0.087 | 0.134 | 0.141 | 0.148 | |
IL-5 | 0.112 | 0.037 | 0.095 | 0.066 | 0.085 | |
IL-6 | -0.317 | -0.079 | -0.250 | -0.151 | -0.210 | |
IL-8 | 0.112 | -0.119 | -0.018 | 0.068 | 0.032 | |
IL-12 p40 | 0.081 | 0.007 | 0.054 | -0.027 | 0.010 | |
IL-12 p70 | -0.056 | -0.079 | -0.091 | -0.175 | -0.148 | |
IL-17a | -0.026 | 0.073 | 0.037 | 0.110 | 0.083 | |
TNF-α | -0.154 | 0.179 | 0.036 | -0.040 | -0.006 | |
IL-1ra | -0.083 | -0.006 | -0.055 | 0.007 | -0.022 | |
IL-4 | -0.238 | 0.053 | -0.106 | -0.097 | -0.108 | |
IL-10 | 0.087 | 0.146 | 0.159 | 0.114 | 0.143 | |
IL-13 | 0.063 | 0.072 | 0.090 | 0.181 | 0.151 | |
Mild tics | GM-CSF | -0.344 | 0.946** | 0.296 | 0.175 | 0.239 |
IFN-α2 | 0.353 | 0.024 | 0.407 | 0.315 | 0.370 | |
IFN-γ | -0.234 | 0.089 | -0.195 | -0.440 | -0.341 | |
IL-1β | -0.070 | 0.228 | 0.085 | -0.037 | 0.019 | |
IL-2 | 0.254 | 0.072 | 0.332 | 0.269 | 0.309 | |
IL-5 | 0.405 | -0.147 | 0.343 | 0.175 | 0.261 | |
IL-6 | -0.070 | 0.104 | -0.003 | 0.167 | 0.093 | |
IL-8 | -0.042 | 0.745** | 0.486 | 0.557 | 0.545 | |
IL-12 p40 | 0.271 | 0.414 | 0.595* | 0.469 | 0.546 | |
IL-12 p70 | -0.682* | 0.321 | -0.524 | -0.583* | -0.577* | |
IL-17a | -0.443 | -0.099 | -0.560 | -0.664* | -0.640* | |
TNF-α | 0.202 | 0.586* | 0.642* | 0.650* | 0.671* | |
IL-1ra | 0.181 | -0.216 | 0.046 | 0.049 | 0.050 | |
IL-4 | -0.294 | 0.915** | 0.329 | 0.142 | 0.236 | |
IL-10 | -0.188 | -0.285 | -0.411 | -0.101 | -0.251 | |
IL-13 | 0.012 | 0.421 | 0.315 | 0.297 | 0.317 | |
Above moderate tics | GM-CSF | -0.192 | -0.143 | -0.250 | -0.144 | -0.206 |
IFN-α2 | 0.020 | -0.062 | -0.035 | -0.145 | -0.116 | |
IFN-γ | -0.326 | -0.004 | -0.234 | -0.153 | -0.206 | |
IL-1β | -0.146 | -0.113 | -0.193 | 0.043 | -0.052 | |
IL-2 | -0.036 | 0.062 | 0.024 | 0.115 | 0.090 | |
IL-5 | -0.143 | 0.009 | -0.094 | 0.040 | -0.012 | |
IL-6 | -0.097 | 0.012 | -0.060 | -0.121 | -0.110 | |
IL-8 | 0.119 | -0.296 | -0.151 | 0.058 | -0.024 | |
IL-12 p40 | -0.103 | -0.178 | -0.215 | -0.232 | -0.252 | |
IL-12 p70 | 0.004 | -0.151 | -0.118 | -0.150 | -0.154 | |
IL-17a | -0.014 | -0.046 | -0.047 | -0.076 | -0.073 | |
TNF-α | -0.317 | 0.154 | -0.102 | -0.134 | -0.136 | |
IL-1ra | 0.165 | -0.056 | 0.073 | 0.096 | 0.098 | |
IL-4 | -0.178 | -0.158 | -0.252 | -0.145 | -0.207 | |
IL-10 | -0.068 | 0.018 | -0.034 | 0.048 | 0.019 | |
IL-13 | -0.108 | -0.191 | -0.229 | 0.047 | -0.064 |