Fig. 2

EA ameliorates abnormal motor evoked potential through miR-212-5p at 7 days after MCAO/R. a Illustrative waveforms of motor evoked potential (MEP) for each group. b The amplitude of MEP for each group. c The latency of MEP for each group. At 7 days after modeling, animals showed lengthened MEP onset latency and reduced peak amplitude post-surgery. The peak amplitude of MEP in the MCAO/R + EA group was significantly increased compared with the MCAO/R group, while, the onset latency of MCAO/R + EA group was significantly shorter than the MCAO/R group. No significant differences between MCAO/R + EA group and MCAO/R + EA + antagomir-NC group were found. Antagomir-212-5p attenuated EA effect on latency and peak amplitude. +: with indicated treatment; −: without indicated treatment. The data are presented as the means ± SEM (n = 6 per group). ^*P < 0.05 and ^**P < 0.01 compared with the Sham group, ^#P < 0.05 and ^##P < 0.01 compared with the MCAO/R group, ^&P < 0.05 and ^&&P < 0.01 compared with the MCAO/R + EA group