Fig. 7
Glutamate clearance under urethane was capable of distinguishing region-dependent differences. (A-C) Under isoflurane, all outcome measures were similar between the cortex, hippocampus, and thalamus. (D) No significant differences were detected in KCl-evoked glutamate release across regions when using urethane. (E-F) Glutamate clearance kinetics under urethane changes as a function of the brain region when evaluating uptake rate (F2,20 = 4.41; p = 0.026) and T80 (F2,14 = 3.79; p = 0.044), where uptake rate was significantly faster and clearance time was significantly shorter in the thalamus compared to the cortex. Bar graphs represent mean + SEM. N = 6–9 per group