Fig. 5
Glutamate uptake rates were similar in the cortex and hippocampus and different in the thalamus of urethane and isoflurane-anesthetized rats. Amplitude-matched signals from local applications of 100 µM exogenous glutamate compared for extracellular glutamate clearance in the cortex, hippocampus, and thalamus. No significant difference in the uptake rate between rats anesthetized with isoflurane or urethane in the (A) cortex (t11 = 0.544, p = 0.597) and (B) hippocampus (t12 = 0.148, p = 0.884). (C) Urethane administration was associated with a significantly faster uptake rate in thalamus than isoflurane (t13 = 2.817, p = 0.0145). Bar graphs represent mean + SEM. N = 6–9 per group