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Table 1 Characteristics of the included trials

From: Mindfulness interventions for craving reduction in substance use disorders and behavioral addictions: systematic review and meta-analysis of randomized controlled trials

STUDY

(author, publication, recruitment, location)

DESIGN

(groups, blinding)

SAMPLE SIZE (intervention/control) at randomization = > outcome timepoint

POPULATION

(males/females/other, diagnosis, consumption status, residential or outpatient)

INTERVENTION

(in patient/app, type, duration, number of sessions, fidelity check, assignments)

CONTROL

(type, limitations)

SCALE

time point

Bowen 2009

USAa, 1 center [17]

RCTb, 2 parallel groups, no blinding

93/75 = > 62/41

107/61 SUDc, medically cleared after 2 weeks of treatment, outpatient settings

In patient, MBRPd, 2 h once a week for 8 weeks (8 sessions), homework assignments (daily exercises on CDe)

TAUf (12 steps based), 1.5 once or twice a week, no homework, no duration matching

PACSg, Week 8

Bevan 2010

USAa, 1 center [21]

RCTb, 2 parallel groups, researcher blind

35/40 => 35/40

42/33 SUDc, probably sober (inpatient SUD settings)

In patient, MBSRh (5 days Tang protocol) + TAUf, daily practice during 5 days

TAUf + Waitlist, no active control

ACQ-Ri, Week 1

Garland 2010

recri2008, USAa, 1 center [11]

RCTb, 2 parallel groups, researcher blind

27/26 = > 18/19

42/11 AUDj, continuous abstinence

In patient, MOREk, 10 weeks, 1 session a week (10 sessions), homework assignments

ASGl (matching themes) ; journaling as homework

PACSg, Week 10

Ruscio 2016

USAa, 1 center [52]

RCTb, 2 parallel groups, participant blind

24/20 = > 18/14

22/22, people who smoke, outpatient settings

PDAm Mindfulness meditation, 2 weeks, daily practice, pre-recorded sessions

Sham meditation

1 to 7 Likert scale, 2 weeks

Li 2017, recri2015, USAa, 1 center [59]

RCTb, 2 parallel groups, dual blinding

15/15 = > 15/14

24/5/1, IGDn (subthreshold included)

In patient, MOREk, 2 h once a week during 8 weeks : 8 sessions, fidelity check, assignments

Support group (active control condition, time matched)

VASo 0–10, 8 weeks

Shorey 2017, recri2012–2013, USAa1 center [28]

RCTb 2 parallel groups, no blinding

64/53 = > 62/47

87/30, SUDc, residential settings, probably sober (28–30 days residential program)

In patient, Residential Mindfulness and Acceptance group therapy, 1.5 h twice a week for 4 weeks (8 sessions) + TAUf, fidelity check, assignments

TAUf (12 steps based, matched on treatment contact time), no structured protocol, no standard group size

PACSg adapted (measures for alcohol and drug craving), 4 weeks

Davis 2018, recri2015–2016, USAa1 center [49]

RCTb, 2 parallel groups, researcher blind

44/35 => 42/31

51/28, SUDc, probably abstinent (residential treatment)

In patient, MBRPd 1.5 h twice a week for 4 weeks (8 sessions) + TAUf, fidelity check, assignments (20–30 min per day)

Up to 8 AAp or NAq meetings + TAUf (time matched), no assignments

GAINr, 4 weeks

Yaghubi 2018, recri2017, Iran, multicenter [60]

RCTb, 2 parallel groups, no blinding

35/35 = > 35/33

Males with OUDs, probably abstinent (MMTt), outpatient settings

In patient, MBRPd + MMTt, 8 weeks, once a week (8 sessions)

MMTt + general information (no active control, not matched)

CBQu, 8 weeks

Black 2019, recri2016–2018, USAa1 center [61]

RCTb, 2 parallel groups, Researcher blind

114/111 = > 90/94

Females with SUDc, probably abstinent, residential settings

In patient, MMWRv, 80 min twice a week for 6 weeks (12 sessions), fidelity check, assignments (mp3)

NAq (time matched), no assignments

PACSg modifié, 6 weeks

Foroushani 2019, Iran, multicenter [54]

RCTb, 4 groups (2 experimental and 2 control), no blinding

15/15/15/15 => 13/12/15/15

Males with OUDs, probably abstinent (MMTt), outpatient settings

In patient, MBRPd + MMTt, 2 h once a week for 8 weeks, no data on fidelity or assignments

MMTt + no intervention, no active control

HCQy (subscales), week 8 (choice of group 1 and 3)

Price 2019, USAa, 3 centers [62]

RCTb, 3 conditions (active control choice), no blinding

93/56 = > 74/46

Females with SUDc, outpatient settings, probably abstinent (after intensive outpatient treatment)

In patient, MABTw 1.5 h once a week for 8 weeks, individual (8 sessions) + TAUf, assignments

TAUf + WHEx (active control, time matched), take home messages

PACSg modified, month 3

Abed 2019, Iran, multicenter [53]

RCTb, 2 parallel groups, no blinding

30/30 = > 24/29

Males with OUDs, probably abstinent (MMTt), outpatient settings

In patient, MBRPd + MMTt, 2 h once a week for 8 weeks (8 sessions), assignments

MMTt + no intervention, no active control

HCQy (subscales), week 8

Weiss de Souza 2020, Brazil, 1 center [63]

RCTb, 2 parallel groups, no blinding

44/42 = > 12/17

17/69; people who smoke, maintenance treatment, outpatient settings

In patient MBRPd 1 h a week for 8 weeks + STz, assignments

STz alone, no active control

QSU+ 1 and 2, 8 weeks

Skrzynski 2023, USAa, 1 center [50]

RCTb, 2 parallel groups, no blinding

89/90 => 75/68

94/88; people who reported drinking > 14/21 drinks/week (for females/males, respectively), wishing to reduce or stop their consumption, outpatient settings

In patient MBRP, once a week for 8 weeks

RP, once a week for 8 weeks

AUQ++ Baseline, mid-treatment and post-treatement

Harby 2021, Egypt, one center [64]

RCTb, 3 parallel groups, open label

20/20/20 = > 15/15/15

Males with OUDs, abstinent, inpatient treatment

In patient group MBRPd, 2 h once a week for 8 weeks

CBT– group setting, 2 h once a week for 8 weeks

or 12-step program, 90 min once a week

OCDUS&, DDQ&&

Zhang 2022, China, one center [65]

RCTb, 2 parallel groups, open label

20/20 = > 19/20

Males with Amphetamine-type stimulant use disorder

10 daily 2-hour class (abbreviated MBRPd) + TAUf

10-day TAUf

VASo: 0 (no craving at all) to 10 (extremely intense

craving)

Massaro 2022 [66]

RCTb, 2 parallel groups, open label

54/54 = > 42/34

92/16, SUDc, outpatient settings, probably abstinent

In patient individual MBRP, once a week for 8 weeks + TAU

CDs for home practice

In patient individual relaxation, once a week for 8 weeks + TAU

CDs for home practice

MACS&&&

  1. aUSA: United States of America, bRCT: Randomized controlled trial, cSUD: Substance Use Disorder, dMBRP: Mindfulness Based Relapse Prevention, eCD: Compact Disk, fTAU: Treatment as usual, gPACS: Penn Alcohol Craving Scale, hMBSR: Mindfulness Based Stress Reduction, iACQ-R: Alcohol Craving Questionnaire revised, jrecr: recruitement, jAUD: Alcohol Use Disorder, kMORE: Mindfulness Oriented Recovery Enhancement, lASG: Alcohol Support Group, mPDA: Personal Digital Assistant, nIGD: Internet Gaming Disorder, oVAS: Visual Analog Scale, pAA: Alcoholics Anonymous, qNA: Narcotics Anonymous, rGAIN: Global Appraisal of Individual Needs, sOUD: Opioid Use Disorder, tMMT: Methadone Maintenance Treatment, uCBQ: Craving Beliefs Questionnaire, vMMWR: Moment-by-Moment in Women’s Recovery, wMABT: Mindful Awareness in Body-oriented Therapy, xWHE: Women’s Health Education, yHCQ: Heroin Craving Questionnaire, zST: Standard Treatment, +QSU: Questionnaire of smoking urges, ++AUQ Alcohol Urge Questionnaire, +++MAT Medication Assisted Treatment, --CBT Cognitive Behavioral Therapy, &OCDUS Obsessive Compulsive Drug Use Scale, &&DDQ Desires for Drug Questionnaire, &&&MACS Multidimentional Alcohol Craving Scale