Skip to main content

Table 3 Non-compartmental pharmacokinetic parameters of roflumilast and zatolmilast following oral administration (10 mg/kg) in mice

From: Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice

Parameter

Roflumilast

Zatolmilast

Tmax (h)

2.33 ± 1.53

2 ± 1.73

Cmax (µg/mL)

0.15 ± 0.07

2.53 ± 0.86

T1/2 (h)

7.13 ± 2.86

20.37 ± 6.77

AUClast (µg·h/mL)

1.13 ± 0.54

30.29 ± 9.64

AUCinf (µg·h/mL)

1.29 ± 0.54

62.05 ± 31.8

 F (%)

2.3

3.7

  1. Data are expressed as the mean ± standard deviation, n = 3; Tmax, time to peak drug concentration; Cmax, peak drug concentration; T1/2, terminal half-life; AUClast, area under the plasma concentration–time curve from 0 to 24 h; AUCinf, area under the plasma concentration–time curve to infinity; F, bioavailability
Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us