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Table 2 Non-compartmental pharmacokinetic parameters of roflumilast and zatolmilast following intravenous administration (1 mg/kg) in mice

From: Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice

Parameter

Roflumilast

Zatolmilast

T1/2 (h)

3.74 ± 0.71

6.35 ± 0.62

AUClast (µg·h/mL)

4.89 ± 0.94

81.88 ± 10.27

AUCinf (µg·h/mL)

5.07 ± 1.10

86.94 ± 10.93

CL (L/h/kg)

0.20 ± 0.05

0.01 ± 0.002

Vss (L/kg)

0.59 ± 0.21

0.07 ± 0.01

  1. Data are expressed as the mean ± standard deviation, n = 3; T1/2, terminal half-life; AUClast, area under the plasma concentration–time curve from 0 to 24 h; AUCinf, area under the plasma concentration–time curve to infinity; CL, Clearance; Vss, volume of distribution at a steady state
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BMC Neuroscience

ISSN: 1471-2202

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