Fig. 5From: Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathwayNoncanonical Wnt signaling for neuronal differentiation with HDAC inhibitors. HDAC inhibitors activate Wnt4, Wnt5α, Wnt 11, and the Fzd receptor. Fzd activates Dvl and stimulates the Wnt/Ca2+ or Wnt/JNK pathway. In the Wnt/Ca2+ pathway, activated Dvl promotes Ca2+, which stimulates PKC. In the Wnt/JNK pathway, activated Dvl promotes phosphorylated ERK and phosphorylated JNK. Finally, c-Jun, a transcription factor, binds to DNA and promotes neuronal differentiation. Here, we demonstrate that Wnt4/5α/11 can modulate Dvl/PKC signaling and the Dvl/p-ERK/p-JNK pathway for neuronal differentiation following HDAC inhibition. Orange color indicates the signaling observed in this studyBack to article page