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Fig. 6 | BMC Neuroscience

Fig. 6

From: Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

Fig. 6

Treatment with 2% H2 and PPARα upregulation significantly increased the expression of ABC efflux transporters (P-gp, MRP2, BCRP) and BBB permeability-associated proteins (ZO-1, occludin, VE-cadherin) in CLP-induced septic mice. (A) The expression of PPARα, MRP2, P-gp, BCRP, ZO-1, VE-cadherin and occludin in the cortex tissues of septic mice was detected by western blot. Quantitative analysis of (B) PPARα, (C) MRP2, (D) P-gp, (E) BCRP, (F) ZO-1, (G) VE-cadherin and (H) occludin are shown as percentage changes of the protein level compared to sham levels. n = 6 mice per group, *P < 0.05 vs. the sham group; #P < 0.05 vs. the CLP group; &P < 0.05 vs. the CLP + H2 group

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BMC Neuroscience

ISSN: 1471-2202

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