Skip to main content
Fig. 5 | BMC Neuroscience

Fig. 5

From: Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

Fig. 5

2% H2 inhalation correlated with PPARα alleviates the brain oedema and BBB disruption induced by sepsis in mice. (A). Representative images of mouse brains were observed at 24 h after the operation, and Evans blue (EB) leakage (blue colour) is evidence of BBB disruption at 24 h after the CLP operation. (B) EB extravasation in brain tissues of each group was quantified; (C). Brain water contents in mice of each group were measured by a dry‒wet method. Values are expressed as the mean ± SD (n = 4 mice per group). *P < 0.05 vs. Sham group; #P < 0.05 vs. CLP group; &P < 0.05 vs. CLP + H2 group

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us